4- (2-羟乙基 )-1 ,3-二氢-2 H -吲哚-2- 酮的合成与结构表征  

Synthesis and Characterization of 4-(2-Hydroxyethyl)-1,3-dihydro-2 H-indol-2-one

作　　者：陈欢生 武华乙 陈兰妹 罗红元 尉洁净 CHEN Huan-sheng;WU Hua-yi;CHEN Lan-mei;LUO Hong-yuan;YU Jie-jing(Department of Pharmacy,Xiamen Medical College,Fujian Xiamen 361023;Xiamen Key Laboratory of Traditional Chinese Medicine Bioengineering,Xiamen Medical College,Fujian Xiamen 361023,China)

机构地区：[1]厦门医学院药学系,福建厦门361023 [2]厦门医学院厦门市中药生物工程重点实验室,福建厦门361023

出　　处：《广州化工》2021年第9期148-150,共3页GuangZhou Chemical Industry

基　　金：厦门医学院校级“金课”项目(XBJK2020027);福建省大学生创新训练项目(202012631017)。

摘　　要：介绍了由科研成果转化形成的药物合成综合实验——4-(2-羟乙基)-1,3-二氢-2 H-吲哚-2-酮的合成。以2-甲基-3-硝基苯乙酸(3)为起始原料,经过4步反应制得4-(2-羟乙基)-1,3-二氢-2 H-吲哚-2-酮,最终产物通过熔点、红外、质谱、氢谱和碳谱进行表征。本实验涉及多种反应类型,结合有机化学波谱解析,可以检验学生的理论水平和训练学生的实验技能。通过系统性的训练,不仅培养了学生的综合实验能力,更提高了学生的创新能力和科研思维。A comprehensive experiment of drug synthesis was introduced,which was developed based on our research work.4-(2-Hydroxyethyl)-1,3-dihydro-2 H-indol-2-one was synthesized,using 2-methyl-3-nitrophenyl acetic acid as the starting material by four-step reactions.The structure of the product was identified by melting point measurements,IR,MS,1H NMR and 13 C NMR.This experiment involved a variety of reaction types,combined with organic chemical spectral analysis,was beneficial for testing theoretical level and improving the synthesis ability of students.Through this systematic training,the students not only cultivated their comprehensive experimental skills,but also enhanced their ability of innovation and scientific thinking.

关 键 词：罗匹尼罗 一锅法合成 综合实验 

分 类 号：G642[文化科学—高等教育学]