子痫前期中表观遗传学改变的研究新进展  

New progress of epigenetic changes in preeclampsia

作　　者：钟琳琳[1] 黄玲玲[1] Zhong Linlin;Huang Lingling(The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院,南宁530021

出　　处：《广西医科大学学报》2021年第4期828-832,共5页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.81760272)。

摘　　要：子痫前期(PE)是一种多因素、多机制及多通路致病的疾病,严重影响孕妇及胎儿的生命安全。PE的病因和发病机制至今不清。目前大量证据表明,表观遗传学与子痫前期的发病存在联系,包括非编码RNA、DNA甲基化、组蛋白修饰及基因组印迹等,这些修饰的改变和PE的发生发展密切相关。本文就PE的表观遗传学改变的研究进展作一综述。Preeclampsia(PE) is a multi-factor, multi-mechanism and multi-channel disease, which seriously affects the life safety of pregnant women and fetuses. The etiology and pathogenesis of PE are still unclear. At present, a large number of evidences show that epigenetics is associated with the pathogenesis of PE, including noncoding RNA, DNA methylation, histone modification and genomic imprinting. These modifications are closely related to the occurrence of PE. In this paper, the research progress of epigenetic changes in PE is reviewed.

关 键 词：子痫前期 表观遗传学 非编码RNA DNA甲基化 组蛋白修饰 基因组印迹 

分 类 号：R714[医药卫生—妇产科学]