参附注射液治疗急性重型脑外伤的临床研究  

Clinical effect of Shenfu Injection on acute severe brain injury

作　　者：卢玺宇 田伟 吴爱玲[1] 刘丛[2] LU Xi-yu;TIAN Wei;WU Ai-ling;LIU Cong(Department of Neurosurgery,Neijiang First People’s Hospital of Sichuan,Neijiang 641000,Sichuan Province,China;Department of Anesthesiology,Neijiang First People’s Hospital of Sichuan,Neijiang 641000,Sichuan Province,China)

机构地区：[1]内江市第一人民医院麻醉科,四川内江641000 [2]内江市第一人民医院神经外科,四川内江641000

出　　处：《中国临床药理学杂志》2021年第8期948-951,共4页The Chinese Journal of Clinical Pharmacology

基　　金：内江市科技计划基金资助项目(Z201951)。

摘　　要：目的观察参附注射液对急性重型脑外伤的治疗效果。方法将71例患者依据术后的用药方法分为对照组与试验组,各34例。对照组术后给予西药治疗:胞磷胆碱纳注射液500 mg+生理盐水250 mL,每天1次,静脉滴注;曲克芦丁脑蛋白水解物注射液400 mg+生理盐水250 mL,每天1次,静脉滴注。试验组术后给予西药治疗+参附注射液:西药治疗方案同对照组,再给予参附注射液30 mL+葡萄糖注射液150 mL(30滴/min),每天2次,静脉滴注。2组的临床疗效观察时间设定为治疗后28 d或死亡。比较2组的临床疗效、昏迷及功能指标、预后情况指标、药物不良反应。结果治疗后,试验组和对照组的总有效率分别为76.47%(26例/34例)和51.35%(19例/37例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的格拉斯哥昏迷量表(GCS)评分分别为(12.35±1.88)和(10.89±1.73)分,功能综合评定量表(FCA)评分分别为(91.68±11.63)和(72.35±21.58)分,差异均有统计学意义(均P<0.05)。试验组和对照组的药物不良反应发生率分别为8.82%(3例/34例)和5.41%(2例/37例),差异无统计学意义(P>0.05)。结论急性重型脑外伤的患者在接受手术治疗的情况下,给予参附注射液联合常规西药进行治疗,有助于患者的神经功能恢复,改善短期的预后,提升治疗效果。Objective To observe the therapeutic effect of Shenfu Injection on acute severe brain injury.Methods The 71 patients were assigned to the control group and the treatment group according to the postoperative medication method,34 cases in each group.The control group was treated with western medicine after operation:Citicoline sodium injection 500 mg+normal saline 250 mL,once a day,intravenous drip;troxerutin cerebroprotein hydrolysate injection 400 mg+normal saline 250 mL,once a day,intravenous drip;treatment group was given western medicine treatment+Shenfu injection after operation:On the basis of the control group,Shenfu injection 30 mL+glucose injection 150 mL(30 drops/min),twice a day,intravenous drip was given.The curative effect observation time of the two groups was set to 28 days after treatment or death.Compare the clinical efficacy,coma and functional indicators,prognostic indicators,and adverse reactions of the two groups.Result After treatment,the total effective rates of the treatment group and the control group were 76.47%(26 cases/34 cases)and 51.35%(19 cases/37 cases),with significant difference(P<0.05).After treatment,the Glasgow Coma Scale(GCS)scores of the treatment group and the control group were 12.35±1.88 and 10.89±1.73,and the functional comprehensive assessment scale(FCA)scores were 91.68±11.63 and 72.35±21.58,with statistically significant difference(all P<0.05).The incidence of adverse drug reactions in the treatment group and the control group was 8.82%(3 cases/34 cases)and 5.41%(2 cases/37 cases),with no significant difference(P>0.05).Conclusion In the case of patients with acute severe brain injury undergoing surgical treatment,Shenfu injection combined with conventional western medicine can help the patient’s neurological function recovery,improve short-term prognosis,and enhance the treatment effect.

关 键 词：参附注射液 脑外伤 氧自由基 神经功能 人参皂苷 

分 类 号：R28[医药卫生—中药学]