间苯三酚和山莨菪碱对肾绞痛急诊患者的临床研究  

A clinical research of phloroglucinol and anisodamine in emergency patients with renal colic

作　　者：高景宇[1] 罗子靖[1] 徐哲 刘静[1] 王磊[1] GAO Jing-yu;LUO Zi-jing;XU Zhe;LIU Jing;WANG Lei(Department of Urology,the First Hospital of Hebei Medical University,Shijiazhuang 050031,Hebei Province,China)

机构地区：[1]河北医科大学第一医院泌尿外科,河北石家庄050031

出　　处：《中国临床药理学杂志》2021年第8期955-958,共4页The Chinese Journal of Clinical Pharmacology

基　　金：2018年度河北省医学科学研究基金资助项目(20180242)。

摘　　要：目的观察间苯三酚和山莨菪碱对肾绞痛急诊患者的疗效及安全性。方法将107例患者分为对照组54例与试验组53例。2组收入住院后首先完成各项基础检查以及对症处理,控制血压、血糖、心率、改善循环、控制尿路感染以及蛋白尿等。对照组予以山莨菪碱:盐酸消旋山莨菪碱注射液10 mg+生理盐水250 mL,每日1次,静脉滴注。试验组予以山莨菪碱+间苯三酚:盐酸消旋山莨菪碱注射液10 mg+间苯三酚注射液80 mg+生理盐水250 mL,每日1次,静脉滴注。2组的治疗效果对比时间均设定为28 d。对比2组的疼痛程度、镇痛起效时间、镇痛缓解持续时间、治疗效果、药物不良反应。结果治疗后,试验组和对照组的总有效率分别为100.00%(53例/53例)和81.48%(44例/54例),差异有统计学意义(P<0.05)。治疗后1 h,试验组和对照组的视觉模拟评分(VAS)分别为(5.23±0.73)和(6.70±0.84)分,治疗后28 d,试验组和对照组的VAS评分分别为(1.15±0.37)和(2.35±0.42)分,差异均有统计学意义(均P<0.05)。试验组和对照组的镇痛起效时间、镇痛缓解持续时间对比,差异有统计学意义(均P<0.05)。试验组和对照组的药物不良反应发生率分别为7.55%(4例/53例)和5.56%(3例/54例),差异无统计学意义(P>0.05)。结论采用间苯三酚联合山莨菪碱治疗方案的策略,有助于迅速缓解患者的疼痛感,提升止痛效果,安全性良好。Objective To observe the efficacy and safety of phloroglucinol and anisodamine in emergency patients with renal colic. Methods The 107 patients were assigned to the control group(54 cases) and the treatment group(53 cases). After the two groups were admitted to hospital, they first completed various basic examinations and symptomatic treatment to control blood pressure, blood sugar, heart rate, improve circulation, control urinary tract infection and proteinuria. The control group received anisodamine: Racemic anisodamine hydrochloride injection 10 mg + normal saline 250 mL, once a day, intravenously. The treatment group received anisodamine+phloroglucinol: Racemic anisodamine hydrochloride injection 10 mg+phloroglucinol injection 80 mg + normal saline 250 mL, once a day, intravenous drip. The treatment effect comparison time of the two groups was set to 28 days. Compare the pain degree, analgesic onset time, analgesic relief duration treatment effect,and adverse drug reactions of the two groups. Result After treatment,the total effective rates of the treatment group and the control group were 100. 00%( 53 cases/53 cases) and 81. 48%( 44 cases/54 cases),with significant difference( P < 0. 05). 1 h after treatment,the visual analogue scale( VAS) scores of the treatment group and control group were 5. 23 ± 0. 73 and 6. 70 ± 0. 84,28 days after treatment,the VAS scores of the treatment group and control group were 1. 15 ± 0. 37 and 2. 35 ± 0. 42,with significant difference( all P < 0. 05). There was a statistically significant difference in the analgesic onset time and the duration of analgesic relief between the treatment group and the control group( all P < 0. 05). The incidence of adverse drug reactions in the treatment group and the control group were 7. 55%( 4 cases/53 cases) and 5. 56%( 3 cases/54 cases),with no significant difference( P > 0. 05). Conclusion The strategy of phloroglucinol combined with anisodamine treatment plan,helps to quickly relieve the pain of patients,improve the analgesic effect,and

关 键 词：间苯三酚 肾绞痛 泌尿系统 疼痛 输尿管 

分 类 号：R28[医药卫生—中药学]