填髓益气方对阿尔茨海默病患者的临床疗效研究  

Clinical effect of Tiansui Yiqi Recipe on patients with Alzheimer's disease

作　　者：李向飞[1] 石小平 张玉芳[3] 尹学永[2] LI Xiangfei;SHI Xiaoping;ZHANG Yufang;YIN Xueyong(Department of Neurology,the Second Hospital of Qinhuangdao,Hebei Qinhuangdao 066600,China;Department of Traditional Chinese Medicine,the Second Hospital of Qinhuangdao,Hebei Qinhuangdao 066600,China;Department of Imaging,the Second Hospital of Qinhuangdao,Hebei Qinhuangdao 066600,China)

机构地区：[1]河北省秦皇岛市第二医院神经内科,河北秦皇岛066600 [2]河北省秦皇岛市第二医院中医内科,河北秦皇岛066600 [3]河北省秦皇岛市第二医院影像科,河北秦皇岛066600

出　　处：《新疆医科大学学报》2021年第5期620-623,共4页Journal of Xinjiang Medical University

基　　金：河北省重点研发计划项目(18277720);秦皇岛市科学技术局项目(201602A231)。

摘　　要：目的研究填髓益气方对阿尔茨海默病患者炎症症状与脑脊液炎性因子及神经递质的影响。方法以2018年7月-2019年7月河北省秦皇岛市第二医院神经内科接受治疗的98例阿尔茨海默病患者为研究对象,随机分为研究组和对照组,每组各49例,对照组采取尼莫地平片等常规西药治疗,研究组在对照组基础上加服填髓益气方,两组患者连续治疗3个疗程。治疗前后,采用酶联免疫吸附法测定患者炎性因子:白细胞介素10(interleukin 10,IL-10)、白细胞介素4(interleukin 4,IL-4)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素6(interleukin 6,IL-6)水平;神经递质:去甲肾上腺素(norepinephrine,NE)、5-羟色胺(5-hydroxytryptamine,5-HT)、多巴胺(dopamine,DA)水平。采用简明精神病评定量表、简易智力状态检查量表、阿尔茨海默病病理行为量表评定患者治疗效果。结果与本组治疗前比较,两组治疗后IL-6和TNF-α水平均减小,NE、5-HT、DA、IL-10和IL-4水平均增大,差异有统计学意义(P<0.05)。与对照组治疗后比较,研究组IL-6和TNF-α水平减小,NE、5-HT、DA、IL-10和IL-4水平增大,差异有统计学意义(P<0.05)。两组治疗后阿尔茨海默病病理行为量表、简明精神病评定量表得分均减小,简易智力状态检查量表得分均增大。与对照组治疗后比较,研究组治疗后病理行为量表和简明精神病评定量表得分减小,简易智力状态检查量表得分增大,差异有统计学意义(P<0.05);与对照组相比,研究组总有效率升高,差异有统计学意义(P<0.05)。结论填髓益气方对AD患者具有良好的临床疗效。Objective To explore the effects of Tiansui Yiqi Recipe on inflammatory symptoms,cerebrospinal fluid inflammatory factors and neurotransmitters in patients with Alzheimer's disease.Methods Nighty eight patients with Alzheimer's disease treated in the Department of Neurology of Qinhuangdao Second Hospital from July 2018 to July 2019 were randomly divided into study group and control group,and each group with 49 cases.The control group was treated with Nimodipine tablets and other conventional western medicine treatments,the study group was added with Tiansui Yiqi recipe on the basis of the control group.Both groups were treated for 3 consecutive courses.Before and after treatment,enzyme-linked immunosorbent assay was used to determine the levels of inflammatory factors in patients:interleukin 10(IL-10),interleukin 4(IL-4),tumor necrosis factor-α(tumor necrosis)factor-α,TNF-α),interleukin 6(IL-6)levels and neurotransmitter levels:such as norepinephrine(NE),5-hydroxytryptamine(5-HT),Dopamine(DA)level.And the Concise Psychiatric Rating Scale,the Simple Intelligence Status Checklist,and the Alzheimer's Disease Pathological Behavior Scale were also employed to assess the treatment status of patients,and record the treatment effect.Results Compared with that before treatment,the levels of IL-6 and TNF-αdecreased,while the levels of NE,5-HT,Da,IL-10 and IL-4 increased in the two groups after treatment,and the difference in the two groups was statistically significant(P<0.05).Compared with the control group,the levels of IL-6 and TNF-αin the study group decreased,while the levels of NE,5-HT,Da,IL-10 and IL-4 in the study group increased(P<0.05).After treatment,the scores of Alzheimer's disease pathological behavior scale and Brief Psychiatric Rating Scale decreased,while the scores of simple mental state examination increased in both groups.Compared with the control group after treatment,the scores of pathological behavior scale and Brief Psychiatric Rating Scale decreased,and the scores of simple mental state examin

关 键 词：阿尔茨海默病 治疗效果 神经递质 炎性因子 填髓益气方 

分 类 号：R242[医药卫生—中医临床基础]