血清基质细胞衍生因子-1水平与糖尿病周围神经病变的相关性  

Association of stromal cell-derived factor 1 with diabeticperipheral neuropathy

作　　者：章惜 王炜[2] 叶山东 周婉 沈秀荣 ZHANG Xi;WANG Wei;YE Shandong(Graduate School,Wannan Medical College,Wuhu 241000,China)

机构地区：[1]皖南医学院研究生学院,安徽芜湖241000 [2]中国科学技术大学附属第一医院(安徽省立医院)内分泌科,中国科学技术大学附属第一医院(安徽省立医院)糖尿病研究室,安徽合肥230001

出　　处：《安徽医学》2021年第4期370-373,共4页Anhui Medical Journal

基　　金：国家自然科学基金项目(项目编号:81971264,81800713);中国科学院脑功能与脑疾病重点实验室开放课题(项目编号:2019-5);安徽省中央引导地方科技发展专项资金(项目编号:2017070802D147)。

摘　　要：目的探索基质细胞衍生因子-1(SDF-1)与糖尿病周围神经病变(DPN)的相关性。方法回顾性分析2018年9月至2019年10月中国科学技术大学附属第一医院(安徽省立医院)内分泌科138例2型糖尿病患者的临床资料,根据有无神经病变,分为无DPN组与DPN组,每组69例。探讨SDF-1与DPN发病的关系。结果DPN组患者SDF-1水平为(0.33±0.17)μg/mL,低于无DPN组,差异有统计学意义(P<0.05);Spearman分析结果显示,SDF-1水平与病程呈负相关(r=-0.178,P<0.05);logistic回归分析显示,血清SDF-1水平降低、病程可能是影响DPN发病的因素(P<0.05)。结论SDF-1水平降低可能与DPN的发病有关。Objective To explore the association of stromal cell-derived factor-1(SDF-1)with diabetic peripheral neuropathy(DPN)in diabetes.Methods A retrospective analysis was performed on the clinical data of 138 patients with type 2 diabetes(T2DM)in the First Affiliated Hospital of USTC from September 2018 to October 2019.According to whether they had peripheral neuropathy,patients were divided into non-DPN group(69 cases)and DNP group(69 cases).The relationship between SDF-1 and the occurrence of DPN was analyzed.Results The level of serum SDF-1 in DPN group was(0.33±0.17)μg/mL,lower than that in non-DNP group.The difference between the two groups was statistically significant(P<0.05).Spearman analysis showed that SDF-1 was negatively associated with the course of disease(r=-0.178,P<0.05).Logistic regression analysis showed that the decreased serum SDF-1 level and the disease term were the factors for the occurrence of DPN(P<0.05).Conclusion Decreased serum SDF-1 level may be associated with DPN in diabetes.

关 键 词：糖尿病 糖尿病周围神经病变 基质细胞衍生因子-1 

分 类 号：R587.2[医药卫生—内分泌]