再生障碍性贫血中医证候与外周血象的相关性分析  

Correlation analysis between TCM syndromes of aplastic anemia and peripheral hemogram

作　　者：付倩倩 吕梦甜 刘文宾[2] 吴迪炯[2] 胡慧瑾[2] 赵越超 沈英英 叶宝东 沈一平[2] 周郁鸿[2] FU Qianqian;LYU Mengtian;LIU Wenbin;WU Dijiong;HU Huijin;ZHAO Yuechao;SHEN Yingying;YE Baodong;SHEN Yiping;ZHOU Yuhong(The First Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou310053,China;Department of Hematology,Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou310006,China)

机构地区：[1]浙江中医药大学第一临床医学院,浙江杭州310053 [2]浙江省中医院血液内科,浙江杭州310006

出　　处：《中国现代医生》2021年第10期13-17,共5页China Modern Doctor

基　　金：浙江省卫计委创新人才资助计划(1S21702)。

摘　　要：目的了解再生障碍性贫血(AA)患者髓劳中医证候分布特点及其与外周血象的相关性。方法回顾性分析2008年12月至2018年10月在浙江省中医院血液科门诊及住院确诊的457例再障患者,根据患者目前的症状、体征和一般情况进行中医证候的收集分析。结果急性再障和慢性再障外周血白细胞(WBC)、中性粒细胞(NE)、淋巴细胞(LY)、血红蛋白(Hb)、血小板(Plt)、C反应蛋白(CRP)、网织红细胞(Ret)比较,差异有统计学意义(P<0.05);中医证候中的发热、盗汗、夜寐、肌肤和肢体感觉比较,差异有统计学意义(P<0.05);外周血象对神疲乏力、心悸气短等11个中医证候的影响比较,差异有统计学意义(P<0.05);头晕目眩、发热、自汗、盗汗及夜寐等中医证候在急慢性再障中出现的频率比较,差异有统计学意义(P<0.05)。结论根据统计学分析得出,Hb、WBC、Plt、Ret升高是中医证候的保护因素;而CRP、NE升高是中医证候的危险因素。Objective To investigate the distribution features of traditional Chinese medicine(TCM)syndromes of aplastic anemia(AA)in patients with myelopathy and its correlation with peripheral hemogram.Methods A total of 457 patients with aplastic anemia diagnosed in outpatient and inpatient department of hematology in Zhejiang Provincial Hospital of Traditional Chinese Medicine from December 2008 to October 2018 were retrospectively analyzed,and the TCM syndromes were collected and analyzed according to current symptoms,signs and general conditions of the patients.Results There were statistically significant differences in white blood cell(WBC),neutrophil(NE),lymphocyte(LY),hemoglobin(Hb),platelet(Plt),C-reactive protein(CRP),reticulocyte(Ret)of peripheral blood between acute and chronic aplastic anemia(P<0.05).There were statistically significant differences in fever,night sweat,night sleep,sensation of skin and limb in TCM syndromes(P<0.05).There were statistically significant differences in impacts of peripheral hemogram on 11 TCM syndromes such as mental fatigue,palpitation and shortness of breath(P<0.05).There were statistically significant differences in the frequency of dizziness,fever,spontaneous perspiration,night sweat and night sleep in TCM syndromes of acute and chronic aplastic anemia(P<0.05).Conclusion According to the statistical analysis,the increases of HB,WBC,PLT and Ret are the protective factors of TCM syndromes,while elevated CRP and NE levels are the risk factors of TCM syndromes.

关 键 词：再生障碍性贫血 中医证候 外周血象 回顾性分析 

分 类 号：R556.5[医药卫生—血液循环系统疾病]