不同剂量生长抑素治疗消化性溃疡出血的疗效及其对胃肠功能的影响研究  

Research on the therapeutic efficacy with different doses of somatostatin on peptic ulcer hemorrhage and its impacts on gastrointestinal function

作　　者：宫健[1] 周新玲 高新英[1] 邢丽 GONG Jian;ZHOU Xinling;GAO Xinying;XING Li(Department of Digestion Medicine,Tai′an City Central Hospital in Shandong Province,Tai′an271000,China;Department of Pain,Tai′an City Central Hospital in Shandong Province,Tai′an271000,China)

机构地区：[1]山东省泰安市中心医院消化内科,山东泰安271000 [2]山东省泰安市中心医院疼痛科,山东泰安271000

出　　处：《中国现代医生》2021年第10期53-56,共4页China Modern Doctor

摘　　要：目的探讨消化性溃疡出血患者在内镜下止血治疗的基础上联合使用不同剂量生长抑素治疗的临床效果。方法选取本院2017年11月至2020年1月收治的消化性溃疡出血的患者96例,所有患者均给予内镜止血联合生长抑素治疗,依据生长抑素使用剂量的不同将96例患者分为A组(使用小剂量生长抑素,n=48)和B组(使用大剂量生长抑素,n=48),比较两组患者的治疗效果。结果两组在治疗前胃动素、胃泌素和生长抑素三项指标水平比较,差异无统计学意义(P>0.05);治疗1周后,B组上述三项胃肠激素指标水平明显低于A组,两组比较,差异有统计学意义(P<0.05)。另外,治疗前,A组和B组转化生长因子-α(TGF-α)、白细胞介素-6(IL-6)和C反应蛋白(CRP)血清指标水平比较,差异无统计学意义(P>0.05);治疗后,B组TGF-α水平高于A组,而IL-6和CRP水平低于A组,两组比较,差异有统计学意义(P<0.05)。B组治疗总有效率(91.67%)与A组(72.92%)比较,B组明显高于A组(P<0.05)。结论在内镜下止血治疗的基础上联合使用大剂量生长抑素可以更好地促进患者胃肠功能的恢复,提高患者的治疗效果,临床应用优势更高于小剂量生长抑素,值得推广实施。Objective To explore the clinical efficacy of endoscopic hemostasis combined with different doses of somatostatin in patients with peptic ulcer hemorrhage(PUH).Methods A total of 96 patients with PUH admitted to our hospital were enrolled in this research.All patients collected from November 2017 to January 2020 were treated with endoscopic hemostasis combined with somatostatin.According to the different doses of somatostatin,96 patients were divided into group A(a small dose of somatostatin was used,n=48)and group B(a large dose of somatostatin was used,n=48).The therapeutic efficacies of the two groups of patients were compared.Results There was no significant differences in the levels of motilin,gastrin and somatostatin between two groups before treatment(P>0.05).After 1 week of treatment,the above 3 gastrointestinal hormone indexes in group B were significantly lower than those in group A,and the differences between the two groups were significant(P<0.05).In addition,before treatment,there were no significant differences in serum levels of transforming growth factor-α(TGF-α),interleukin-6(IL-6)and C-reactive protein(CRP)between Group A and Group B(P>0.05).After treatment,the level of TGF-αin group B was higher than that in group A,while the levels of IL-6 and CRP were lower than those in group A,with statistically significant differences between the two groups(P<0.05).The total efficacy rate of group B was 91.67%,significantly higher than 72.92%of group A(P<0.05).Conclusion Combined use of large-dose somatostatin on the basis of endoscopic hemostasis can better promote the recovery of gastrointestinal function and improve the therapeutic efficacy of patients.Its clinical application advantage is higher than that of small-dose somatostatin,which is worthy of promotion and implementation.

关 键 词：消化性溃疡出血 生长抑素 用药剂量 胃肠激素水平 治疗效果 

分 类 号：R975[医药卫生—药品]