智七针联合六味地黄汤对缺血缺氧性脑病患儿的疗效及血液流变学的影响  

Effect of Zhiqi acupuncture combined with Liuwei Dihuang Decoction on children with hypoxic-ischemic encephalopathy and hemorheology

作　　者：曲笛[1] QU Di(Department of Rehabilitation,Shenyang Children’s Hospital,Shenyang 110031,China)

机构地区：[1]沈阳市儿童医院康复科,沈阳110031

出　　处：《吉林中医药》2021年第4期493-496,共4页Jilin Journal of Chinese Medicine

基　　金：国家重点研发计划(2016YFC1306200)。

摘　　要：目的探讨智七针联合六味地黄汤对缺血缺氧性脑病患儿的疗效及血液流变学的影响。方法将我院共计86例缺血缺氧性脑病患儿分为2组,对照组43例,采用现代康复训练治疗;在此基础上,观察组采用智七针联合六味地黄汤治疗,持续治疗8周。评价2组患儿的疗效,治疗前、治疗2周、治疗4周和治疗8周评估粗大运动功能评定量表(Grossmotor function measure,GMFM),治疗前后测定白介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和血浆全血黏度(高切、低切)、血浆黏度。结果对照组总有效率为74.42%,低于观察组的90.70%,差异有统计学意义(P<0.05)。与治疗前比较,2组患者治疗2周、治疗4周、治疗8周GMFM量表评分升高;与对照组比较,观察组患者治疗2周、治疗4周、治疗8周GMFM量表评分较高,差异有统计学意义(P<0.05)。与治疗前比较,2组治疗8周血清IL-6、TNF-α水平降低;与对照组比较,观察组治疗8周血清IL-6、TNF-α水平较低,差异有统计学意义(P<0.05)。与治疗前比较,2组治疗8周高切全血黏度、低切全血黏度和血浆黏度降低;与对照组比较,观察组治疗8周高切全血黏度、低切全血黏度和血浆黏度较低,差异有统计学意义(P<0.05)。结论智七针联合六味地黄汤对缺血缺氧性脑病患儿的疗效显著,可以改善炎症因子和血液流变学,提高运动功能。Objective To investigate the effect of Zhiqi acupuncture combined with Liuwei Dihuang Decoction on children with hypoxic-ischemic encephalopathy(HIE)and hemorheology.Methods A total of 86 children with hypoxic-ischemic encephalopathy in our hospital were divided into two groups,wtih 43 cases in each group.The control group were treated with modern rehabilitation training,while the observation group were treated with Zhiqi acupuncture combined with Liuwei Dihuang Decoction on the basis of the control group.Both groups received the corresponding treatment for 8 weeks.The curative effects of the two groups were evaluated.Gross motor function measure(GMFM)was evaluated before treatment,2 weeks,4 weeks and 8 weeks after treatment.Interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),whole blood viscosity(high cut,low cut)and plasma viscosity were measured before and after treatment.Results The effective rate(74.42%)in the control group was lower than that in the observation group(90.70%),and the difference was statistically significant(P<0.05).Compared with before treatment,the GMFM scale scores of the two groups were increased after 2 weeks,4 weeks,and 8 weeks of treatment.Compared with the control group,the GMFM scale scores of the observation group were higher after 2 weeks,4 weeks,and 8 weeks of treatment,and the difference was statistically significant(P<0.05).Compared with before treatment,the serum IL-6 and TNF-αlevels of the two groups were reduced after 8 weeks of treatment.Compared with the control group,the serum IL-6 and TNF-αlevels of the observation group were lower after 8 weeks of treatment,and the difference was statistically significant(P<0.05).Compared with before treatment,the high-cut whole blood viscosity,low-cut whole blood viscosity and plasma viscosity were decreased after 8 weeks of treatment,and the high-cut whole blood viscosity,low-cut whole blood viscosity and plasma viscosity in the observation group were lower than that in the control group,with a statistically significant difference(P

关 键 词：智七针 六味地黄汤 缺血缺氧性脑病 炎症因子 血液流变学 

分 类 号：R722.1[医药卫生—儿科]