菌群-肠脑轴与疾病相关性研究进展及其干预对健康生活的展望  

Research progress on the relationship between the microbiota-gut-brain axis and diseases and the prospect of intervention on healthy life

作　　者：申静 SHEN Jing(SPH Sine Pharmaceutical Laboratories Co.,Ltd.,Shanghai 201206,China)

机构地区：[1]上海上药信谊药厂有限公司,上海201206

出　　处：《上海医药》2021年第9期76-80,共5页Shanghai Medical & Pharmaceutical Journal

摘　　要：肠道菌群是个巨大、复杂的微生物生态系统,其中菌群-肠脑轴是近年研究热点。大量研究发现菌群-肠脑轴通过对免疫系统、神经传递、内分泌调节及菌群代谢物的调控,产生对精神疾病及神经退行性病变的影响。由此,深度启发了更多治疗方式和益生菌产品的发展,以预防及治疗相关疾病,具有很好的社会效益和经济学价值。本文综述了其在治疗及健康管理中的作用及商业开发价值。Intestinal microflora is a huge and complex microbial ecosystem,in which the microbiota-gut-brain axis has been a research hotspot in recent years.A large number of studies have showed that the microbiota-gut-brain axis has an impact on mental diseases and neurodegenerative diseases by the regulation of immune system,neurotransmission,endocrine regulation and flora metabolites.Therefore,more treatment methods and probiotics products are deeply inspired to prevent and treat the related diseases,which has good social benefits and economic value.The role of probiotics in clinical treatment and health management and its commercial development value are reviewed.

关 键 词：菌群-肠脑轴 神经退行性疾病 干预 

分 类 号：R37[医药卫生—病原生物学] R363[医药卫生—基础医学]