银杏叶提取物注射液联合倍他司汀治疗突发性耳聋临床疗效  

Clinical effect of Ginkgo biloba injection combined with betahistine in treatment of sudden deafness

作　　者：汪身正 Wang Shenzheng(Yichun People's Hospital of Jiangxi Province,Jiangxi 336000)

机构地区：[1]江西省宜春市人民医院,江西336000

出　　处：《天津药学》2021年第2期31-34,共4页Tianjin Pharmacy

摘　　要：目的:探讨银杏叶提取物注射液联合倍他司汀治疗突发性耳聋临床疗效。方法:随机数字表法将2019年1月—2020年1月本院接受治疗的80例突发性耳聋患者分为观察组与对照组各40例。两组均给予基础治疗,同时两组均口服倍他司汀,6 mg/次,3次/d;观察组在此基础上加用银杏叶提取物注射液,87.5 mg/次,1次/d,加入到250 ml氯化钠注射液中静脉滴注。两组均连续治疗10 d。治疗前和治疗10 d时检测并比较内耳微循环及血液流变学相关指标,比较两组治疗前、治疗3 d和治疗10 d时的听阈水平,统计两组治疗期间不良反应。结果:治疗10 d两组基底动脉管径、小脑前下动脉管径、内听动脉管径均较治疗前扩大(P<0.05),且观察组改善优于对照组(P<0.05);治疗10 d两组血小板聚集率、血浆黏度均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05);治疗3 d和10 d两组听阈水平均较治疗前降低(P<0.05),且观察组治疗后各时点均低于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:倍他司汀治疗基础上联合银杏叶提取物注射液治疗突发性耳聋,可以调节患者的内耳微循环及血液流变学,降低突发性耳聋患者听阈水平,未增加不良反应,安全性好。Objective:To investigate the clinical effect of Ginkgo biloba injection combined with betahistine in the treatment of sudden deafness.Methods:According to the random number table method,a total of 80 patients with sudden deafness treated in the hospital from January 2019 to January 2020 were divided into observation group and control group with 40 cases in each group.Both groups were given basic treatment,and betahistine was given orally with 6 mg/time,three times/d.The observation group was additively treated with Ginkgo biloba injection by intravenous drip,with 87.5 mg/time(prepared with 250 ml normal saline),once a day.Both groups were treated continuously for ten days.Inner ear microcirculation and hemorheology indexes were detected and compared before treatment and at ten days of treatment.Moreover,hearing threshold levels were compared between both groups before treatment,three days of treatment,and ten days of treatment.Adverse reactions during treatment were evaluated between both groups.Results:After ten days of treatment,the diameter of the basilar artery,anterior inferior cerebellar artery,and the internal auditory artery in both groups were larger than before treatment(P<0.05).The improvement in the observation group was better than that in the control group(P<0.05).After ten days of treatment,the platelet aggregation rate and plasma viscosity in both groups were lower than before treatment(P<0.05),and the observation group was lower than the control group(P<0.05).After three-and ten-day treatment,the level of hearing threshold in both groups was lower than that before treatment(P<0.05),and the observation group was lower than the control group at all time points after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Betahistine combined with ginkgo biloba injection in the treatment of sudden deafness can regulate the inner ear microcirculation and hemorheology of patients,reduce the level of hearing threshold in pati

关 键 词：突发性耳聋 银杏叶提取物注射液 倍他司汀 内耳微循环 血液流变学 听阈 不良反应 

分 类 号：R987[医药卫生—药品]