冻融囊胚移植前HCG宫腔灌注对IVF-ET反复种植失败患者妊娠结局的影响  

Effect of HCG intrauterine perfusion before frozen-thawed blastocyst transplantation on pregnancy outcome in patients with recurrent implantation failure of IVF-ET

作　　者：熊永崂[1] 蔡桂丰[1] 杨桂艳[1] 周雯雯[1] 梁晓燕[2] XIONG Yong-lao;CAI Gui-feng;YANG Gui-yan;ZHOU Wen-wen;LIANG Xiao-yan(Zhuhai Women and Children’s Hospital,Zhuhai 519000;The Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou 510000)

机构地区：[1]珠海市妇幼保健院生殖中心,珠海519000 [2]中山大学附属第六医院生殖中心,广州510000

出　　处：《生殖医学杂志》2021年第5期616-619,共4页Journal of Reproductive Medicine

基　　金：珠海市科技计划项目(ZH2202200064HJL)。

摘　　要：目的评估冷冻囊胚移植前人绒毛膜促性腺激素(HCG)宫腔灌注对体外受精-胚胎移植(IVF-ET)反复种植失败患者的治疗效果。方法回顾性分析2018年1月至2019年12月在珠海市妇幼保健院生殖中心就诊、因反复种植失败再次行冻融囊胚移植患者的临床资料,根据再次移植前是否进行宫腔灌注分为灌注组(移植前给予HCG宫腔灌注,n=52)和未灌注组(n=108)。比较两组患者的基本资料、临床妊娠率、活产率及流产率等妊娠结局。结果两组患者的年龄、体重指数(BMI)、不孕年限、FSH、LH、E 2、取卵周期数、移植周期数、既往移植胚胎数比较均无显著性差异(P>0.05)。灌注组的囊胚种植率(53.2%vs.30.6%)、生化妊娠率(28.8%vs.13.0%)、临床妊娠率(53.8%vs.32.4%)、活产率(48.1%vs.28.7%)均显著高于未灌注组(P<0.05)。两组的流产率比较无显著性差异(P>0.05)。结论冻融囊胚移植前HCG宫腔灌注可明显改善IVF-ET反复种植失败患者的临床结局。Objective:To investigate the efficacy of HCG intrauterine perfusion before frozen-thawed blastocyst transplantation on pregnancy outcome in patients with recurrent implantation failure of IVF-ET.Methods:The clinical data of the frozen-thawed embryo transfer cycles of the patients with recurrent implantation failure in Zhuhai Women and Children’s Hospital from Jan.2018 to Dec.2019 were retrospectively analyzed.The patients were divided into perfusion group(HCG intrauterine perfusion before transplantation,n=52)and non-perfusion group(n=108).The basic data,clinical pregnancy rate,live birth rate and abortion rate of the two groups were compared.Results:There were no significant differences in age,body mass index(BMI),infertility years,FSH,LH,E 2,number of oocyte retrieval cycles,number of transfer cycles and number of previously transferred embryos between the two groups(P>0.05).The blastocyst implantation rate(53.2%vs.30.6%),biochemical pregnancy rate(28.8%vs.13.0%),clinical pregnancy rate(53.8%vs.32.4%)and live birth rate(48.1%vs.28.7%)in perfusion group were significantly higher than those in non-perfusion group(P<0.05).There was no significant difference in abortion rate between the two groups(P>0.05).Conclusions:HCG intrauterine perfusion before frozen-thawed blastocyst transplantation can significantly improve clinical outcome in the women with recurrent implantation failure.

关 键 词：人绒毛膜促性腺激素 宫腔灌注 冻融囊胚移植 反复种植失败 

分 类 号：R711.6[医药卫生—妇产科学]