硒对自身免疫性甲状腺炎中调节性T细胞影响的研究进展  

Effect of selenium on regulatory T cells in patients with autoimmune thyroiditis

作　　者：李玥 宋守君[1] 薛海波[1] Li Yue;Song Shoujun;Xue Haibo(Department of Endocrinology,Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院内分泌科,山东256603

出　　处：《国际医药卫生导报》2021年第7期960-963,共4页International Medicine and Health Guidance News

基　　金：山东省自然科学基金(面上项目)(ZR2013HM049);山东省重点研发计划(2016GSF201021)。

摘　　要：自身免疫性甲状腺炎(autoimmune thyroiditis,AIT)是以甲状腺的淋巴细胞浸润和甲状腺自身抗体的产生为特征的一种自身免疫性疾病,调节性T细胞参与了AIT的发生发展。微量元素硒水平与AIT密切相关,并且可以调控调节性T细胞的分化与功能。本文就硒对AIT中调节性T细胞影响的研究进展做一综述。Autoimmune thyroiditis is an autoimmune disease characterized by lymphocytic infiltration of thyroid gland and by production of thyroid autoantibodies.Regulatory T cells play a role in the incidence and development of autoimmune disease.Many studies have proved that blood selenium level is closely related to the occurrence and development of autoimmune thyroiditis,and it also can regulate the differentiation and function of regulatory T cells.This review focuses on the effect of selenium on regulatory T cells in patients with autoimmune thyroiditis.

关 键 词：自身免疫性甲状腺炎 硒 调节性T细胞 

分 类 号：R581.4[医药卫生—内分泌]