糖尿病肾病分子机制的研究新进展  

New progress in the research on molecular mechanism of diabetic nephropathy

作　　者：张志蓉 韩伟霞[1] 王晨[1] Zhang Zhirong;Han Weixia;Wang Chen(Department of Pathology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China)

机构地区：[1]山西医科大学第二医院病理科,太原030001

出　　处：《中华肾病研究电子杂志》2021年第2期90-95,共6页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

摘　　要：糖尿病肾病(DN)是糖尿病严重的微血管并发症,是引起终末期肾病(ESRD)的主要原因。DN发病机制复杂,包括糖与脂代谢紊乱、血流动力学异常、氧化应激及炎症。近年研究发现,非编码RNA、自噬、焦亡和外泌体等在DN发展中发挥重要作用。本文就以上分子机制的最新研究进展予以综述,以期对早期诊断、个体化精准治疗和延缓DN进展提供新的见解。Diabetic nephropathy(DN)is a serious microvascular complication of diabetes,and is the main cause of end-stage renal disease(ESRD).The pathogenesis of DN is complex,including glucose and lipid metabolism disorders,abnormal hemodynamics,oxidative stress,and inflammation.Recent studies have found that non-coding RNA,autophagy,pyroptosis,and exosomes,etc,play an important role in the development of DN.This article reviewed the latest research progress of the above molecular mechanisms in order to provide new insights on early diagnosis,individualized precision treatment,and delaying of DN progression.

关 键 词：糖尿病肾病 非编码RNA 自噬 焦亡 外泌体 

分 类 号：R58[医药卫生—内分泌]