腺相关病毒与肾小管靶向基因转导  

Adeno-associated virus and renal tubular-targeted gene transduction

作　　者：马强[1] 敖强国[1] 张雅宾[1] 程庆砾[1] Ma Qiang;Ao Qiangguo;Zhang Yabin;Cheng Qingli(Department of Nephrology and National Institute of Geriatrics, Second Medical Center of General Hospital of Chinese PLA, Beijing 100853, China)

机构地区：[1]解放军总医院第二医学中心肾脏病科暨全国老年病研究所,北京100853

出　　处：《中华肾病研究电子杂志》2021年第2期113-116,共4页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

摘　　要：肾脏的基因治疗近些年研究较多并取得了一定的进展,其研究热点主要集中在腺相关病毒。本文概述了腺相关病毒在基因转导的研究进展,综述了靶向肾小管的基因转导的不同途径和基因载体,探讨了腺相关病毒靶向肾小管的基因转导策略及存在的问题。Renal gene therapy has been studied in recent years,and some progress has been made.The research focus was mainly on adeno-associated virus.This article summarized the research progress of adeno-associated virus in gene transduction,reviewed the different transduction pathways and gene vectors of gene transduction targeting the renal tubules,and discussed the gene transduction strategies and the existing problems in adeno-associated virus gene transduction targeting the renal tubules.

关 键 词：腺相关病毒 肾小管 基因转导 

分 类 号：R73[医药卫生—肿瘤]