自拟通窍定眩汤联合甲磺酸倍他司汀片治疗痰瘀阻窍型后循环缺血性眩晕的疗效观察  

Efficacy of Self-Made Tongqiao Dingxuan Decoction Combined with Betahistine Mesylate Tablets in the Treatment of Posterior Circulation Ischemic Vertigo with Phlegm Stasis Obstruction

作　　者：何玉华 刘伟[1] 吴晓霓 顾秀竹 袁强[2] HE Yuhua;LIU Wei;WU Xiaoni;GU Xiuzhu;Yuan Qiang(Dept.of Pharmacy,West China Hospital,Sichuan University,Sichuan Chengdu 610041,China;Dept.of Neurology,West China Hospital,Sichuan University,Sichuan Chengdu 610041,China)

机构地区：[1]四川大学华西医院临床药学部,四川成都610041 [2]四川大学华西医院神经内科,四川成都610041

出　　处：《中国医院用药评价与分析》2021年第4期416-419,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：四川省中医药科研项目(No.2017Z015)。

摘　　要：目的:探讨自拟通窍定眩汤联合甲磺酸倍他司汀片治疗痰瘀阻窍型后循环缺血性眩晕的临床治疗效果。方法:选取2017—2019年四川大学华西医院收治的痰瘀阻窍型后循环缺血性眩晕患者96例,采用随机数字表法分成对照组、研究组,每组48例。对照组患者给予甲磺酸倍他司汀片治疗,研究组患者在对照组的基础上联合应用自拟通窍定眩汤治疗,均治疗14 d。比较两组患者的临床疗效、中医证候积分及血液流变学指标改善情况的差异,记录两组患者的不良反应发生情况。结果:研究组患者临床总有效率为93.75%(45/48),较对照组的68.75%(33/48)明显更高,差异有统计学意义(P<0.05)。治疗1个疗程后,两组患者头晕目眩、恶心呕吐、倦怠乏力、耳鸣耳聋及头重如蒙等症状积分,血浆黏度、全血黏度和纤维蛋白原水平均较治疗前明显降低,且研究组患者较对照组明显更低,上述差异均有统计学意义(P<0.05)。两组患者椎动脉平均血流速度、基底动脉平均血流速度较治疗前明显升高,且研究组患者较对照组明显更高,上述差异均有统计学意义(P<0.05)。对照组、研究组患者的不良反应发生率分别为8.33%(4/48)、12.50%(6/48),两组比较,差异无统计学意义(P>0.05)。结论:自拟通窍定眩汤联合甲磺酸倍他司汀片治疗痰瘀阻窍型后循环缺血性眩晕的疗效确切,能改善临床症状及血液流变学指标,且安全性较高。OBJECTIVE:To probe into the treatment effects of self-made Tongqiao Dingxuan decoction combined with Betahistine mesylate tablets in the treatment of posterior circulation ischemic vertigo with phlegm stasis obstruction.METHODS:Totally 96 patients with posterior circulation ischemic vertigo with phlegm stasis obstruction admitted into West China Hospital,Sichuan University from 2017 to 2019 were extracted to be divided into the control group and the study group via the random number table,with 48 cases in each group.The control group was treated with Betahistine mesylate tablets,while the study group received self-made Tongqiao Dingxuan decoction on the basis of the control group.Two groups were treated for 14 d.The differences in clinical efficacy,traditional Chinese medicine syndrome score and improvement of hemorheology indicators between two groups were compared,and the incidence of adverse drug reactions was recorded.RESULTS:The total clinical effective rate of the study group was93.75%(45/48),significantly higher than the control group 68.75%(33/48),the difference was statistically significant(P<0.05).After one course of treatment,symptom scores of vertigo,nausea and vomiting,fatigue,tinnitus and deafness and clouded heavy head,plasma viscosity,whole blood viscosity and fibrinogen level in both groups were significantly lower than those before treatment,and the study group was lower than the control group,with statistically significant difference(P<0.05).The mean blood flow velocity of vertebral artery and basilar artery in two groups were significantly higher than those before treatment,and the study group was higher than the control group,with statistically significant difference(P<0.05).The incidence of adverse drug reactions in control group and study group was respectively 8.33%(4/48)and 12.50%(6/48),there was no significant difference between two groups(P>0.05).CONCLUSIONS:The efficacy of self-made Tongqiao Dingxuan decoction combined with Betahistine mesylate tablets in the treatment of posterior cir

关 键 词：自拟 通窍定眩汤 后循环缺血 眩晕 临床效果 

分 类 号：R932[医药卫生—生药学]