血清Hcy、HTL水平与冠心病患者颈动脉粥样硬化的相关性研究  

Correlation between serum Hcy,HTL levels,and carotid atherosclerosis in patients with coronary heart disease

作　　者：高汝威 曾令恒 操龙斌 GAO Ru-wei;ZENG Ling-heng;CAO Long-bin(Department of Laboratory Medicine,Nanhai Hospital of Southern Medical University,Foshan 528244,Guangdong,CHINA)

机构地区：[1]南方医科大学南海医院检验科,广东佛山528244

出　　处：《海南医学》2021年第9期1109-1111,共3页Hainan Medical Journal

基　　金：广东省佛山市卫生健康局医学科研课题立项项目(编号:20200272)。

摘　　要：目的研究血清同型半胱氨酸(Hcy)、同型半胱氨酸硫内酯(HTL)复合物水平与冠心病患者颈动脉粥样硬化的相关性。方法选取南方医科大学南海医院2019年6月至2020年6月期间收治的108例冠心病患者作为研究组,另选取本院同期健康体检者108例作为对照组。采用荧光高压液相法(HPLC)测定血清Hcy水平,采用竞争性酶联免疫吸附法(ELISA)测定血清HTL复合物水平,采用彩色多普勒超声法测定颈动脉粥样硬化情况,采用Pearson相关分析法分析血清Hcy、HTL水平与颈动脉斑块积分的相关性,采用多元Logistic回归分析探究导致颈动脉粥样硬化发生的独立危险因素。结果研究组患者的血清Hcy、HTL水平分别为(20.43±2.63)μmol/L、(32.26±6.84)U/mL,明显高于对照组的(12.52±2.37)μmol/L、(22.58±5.37)U/mL,差异均有统计学意义(P<0.05);研究组患者的颈动脉粥样硬化、内膜增厚、斑块形成检出率分别为66.7%、19.4%、47.2%,斑块积分为(4.25±1.42)分,明显高于对照组的5.5%、3.7%、1.9%和(0.53±0.12)分,差异均有统计学意义(P<0.05);血清Hcy、HTL水平与颈动脉斑块积分均呈正相关(r=0.437、0.383,P<0.05);以颈动脉粥样硬化为因变量,以Hcy、HTL为自变量做Logistic回归分析,结果显示,血清Hcy、HTL水平升高是冠心病患者颈动脉粥样硬化发病的独立危险因素(P<0.05)。结论冠心病患者血清Hcy、HTL水平与颈动脉粥样硬化发生呈正相关,血清Hcy、HTL水平的监测对冠心病患者颈动脉粥样硬化疾病的诊断、预防及治疗有重要意义。Objective To study the correlation between serum homocysteine(Hcy),homocysteine thiolactone(HTL)complex levels and carotid atherosclerosis in patients with coronary heart disease.Methods A total of 108 patients with coronary heart disease admitted to Nanhai Hospital of Southern Medical University from June 2019 to June 2020 were selected as the study group,and 108 healthy people in Nanhai Hospital of Southern Medical University during the same period were selected as the control group.The serum Hcy level was determined by high-pressure liquid chromatography(HPLC),the serum HTL complex level was determined by competitive enzyme-linked immunosorbent assay(ELISA),and the carotid atherosclerosis was determined by color Doppler ultrasound.Pearson correlation analysis was used to analyze the correlation between serum Hcy,HTL levels,and carotid plaque score.Multivariate logistic regression analysis was used to explore the independent risk factors of carotid atherosclerosis.Results The serum levels of Hcy and HTL in the study group were(20.43±2.63)μmol/L and(32.26±6.84)U/mL,respectively,which were significantly higher than(12.52±2.37)μmol/L and(22.58±5.37)U/mL in the control group(P<0.05).The detection rates of carotid atherosclerosis,intimal thickening and plaque formation in the study group were 66.7%,19.4%,and 47.2%,and the plaque score was(4.25±1.42)points,which was significantly higher than 5.5%,3.7%,1.9%,and(0.53±0.12)points in the control group(P<0.05).Serum Hcy and HTL levels were positively correlated with carotid plaque score(r=0.437,0.383,P<0.05).Logistic regression analysis with carotid atherosclerosis as the dependent variable and Hcy and HTL as the independent variables showed that the increase of serum Hcy and HTL levels was an independent risk factor of carotid atherosclerosis in patients with coronary heart disease(P<0.05).Conclusion Serum Hcy and HTL levels are positively correlated with the occurrence of carotid atherosclerosis in patients with coronary heart disease.The monitoring of serum Hcy

关 键 词：冠心病 颈动脉 粥样硬化 同型半胱氨酸 同型半胱氨酸硫内酯 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]