睾丸间质细胞睾酮合成机制的研究进展  

Research Progress on the Mechanism of Testosterone Synthesis in Leydig Cells

作　　者：朱清玉 郭乐薇 刘红羽[1,2] 赵静 吕文发[1,2] 王军 ZHU Qingyu;GUO Lewei;LIU Hongyu;ZHAO Jing;LYU Wenfa;WANG Jun(Joint Laboratory of Modern Agricultural Technology International Cooperation,Ministry of Education,Jilin Agricultural University,Jilin Changchun 130118,China;Key Lab of Animal Production,Product Quality and Security,Ministry of Education,Jilin Agricultural University,Jilin Changchun 130118,China)

机构地区：[1]吉林农业大学现代农业技术教育部国际合作联合重点实验室,吉林长春130118 [2]吉林农业大学动物生产及产品质量安全教育部重点实验室,吉林长春130118

出　　处：《中国畜牧杂志》2021年第5期28-33,共6页Chinese Journal of Animal Science

基　　金：国家重点研发计划项目(2016YFD0500502)。

摘　　要：睾酮是雄性动物最重要的性激素之一,主要以胆固醇为原料由睾丸间质细胞合成。睾酮参与调节机体内重要的生理过程,对精子发生以及维持其他组织器官正常的生理活动具有重要意义。睾酮的合成涉及多种信号通路、细胞因子、转录因子和非编码RNA的调控。本文综述了睾丸间质细胞睾酮合成机制的研究进展,为睾酮合成的进一步研究提供参考。Testosterone is one of the most important sex hormones in male animals mainly synthesized from cholesterol in Leydig cells.Testosterone is involved in regulating important physiological processes in vivo,which is significant for sperm genesis and maintaining normal physiological activities of other tissues and organs.The synthesis of testosterone is complex,involving multiple signaling pathways,cytokines,transcription factors and non-coding RNA regulation.In this paper,we reviewed the research progress of testosterone synthesis mechanism in Leydig cells,and provided reference for further research on testosterone synthesis.

关 键 词：睾酮 间质细胞 胆固醇 合成机制 

分 类 号：S814[农业科学—畜牧学]