miRNA调节乳腺组织脂肪代谢的研究进展  

Research Progress on the Role of MicroRNA in Regulation of Mammary Gland Fat Metabolism

作　　者：马青山 王长法 刘桂芹[1] 李艳 MA Qingshan;WANG Changfa;LIU Guiqin;LI Yan(College of Agronomy,Liaocheng University,Shandong Engineering Technology Research Center for Efficient Breeding and Ecological Feeding of Black Donkey,Shandong Donkey Industry Technology Collaborative Innovation Center,Shandong Liaocheng 252000,China)

机构地区：[1]聊城大学农学院,山东省黑毛驴高效繁育与生态饲养工程技术研究中心,山东省驴产业科技协同创新中心,山东聊城252000

出　　处：《中国畜牧杂志》2021年第5期40-47,共8页Chinese Journal of Animal Science

基　　金：国家自然科学基金(31671287);山东省“泰山产业领军人才”项目(LJNY201713);山东省现代农业产业技术体系驴产业创新团队项目(SDAIT-27);山东省农业良种工程项目(2017LZGC020)。

摘　　要：乳脂是影响乳品口感和营养价值的关键因素。乳腺组织脂肪代谢受到众多激素和信号分子的调控,其中microRNA(miRNA)作为乳脂代谢的重要调控因子受到持续关注。本文简要介绍了miRNA生物合成过程,总结了主要参与机体脂质代谢调控的miRNA,综述了近年来miRNA调节乳脂合成、转运、氧化及分泌等过程的相关研究进展,并对其靶基因和功能进行了梳理,以期为进一步研究乳腺组织脂肪代谢调控机制提供参考。Milk fat is a key factor that affects the taste and nutritional value of dairy products.Fat metabolism in breast tissue is regulated by many hormones and signal molecules.Among them,microRNAs(miRNAs)have received much attention as important regulators of milk fat metabolism.Here,we present a brief introduction to miRNAs biosynthesis and its database,summarize the miRNAs related to lipid metabolism and the studies on the role of miRNAs in regulating milk fat synthesis,transport,oxidation and secretion,and sort out their target genes and functions.This paper would provide an important reference for further study on the regulation mechanism of mammary gland lipid metabolism.

关 键 词：MIRNA 调节 乳脂代谢 

分 类 号：S811[农业科学—畜牧学]