皮肤型Rosai-Dorfman病临床研究进展  

Clinical research progress of cutaneous Rosai-Dorfman disease

作　　者：张彦秀[1] 郑宝勇[1] 聂廷芬[1] ZHANG Yan-xiu;ZHENG Bao-yong;NIE Ting-fen(Derpartment of Dermatology,Baodi Clinical College of Tianjin Medical University,Tianjin 301800,China)

机构地区：[1]天津医科大学宝坻临床学院皮肤科,天津301800

出　　处：《皮肤病与性病》2021年第2期181-183,共3页Dermatology and Venereology

摘　　要：Rosai-Dorfman病是一种良性的少见疾病,其特征是组织细胞过度产生和积累于身体的淋巴结及结外部位,结外累及仅限于皮肤的称皮肤Rosai-Dorfman病(CRDD)。CRDD临床表现无特异性,病理学特征为大量的RDD细胞,以及淋巴细胞和浆细胞等炎细胞浸润,可见伸入运动,即部分组织细胞内可见被吞噬的完整的淋巴细胞、嗜中性粒细胞等。CRDD大多是自限性的,通常不需要积极干预。目前,手术被认为是治疗小面积皮损最有效的方法。Rosai-Dorfman disease(RDD)is a rare benign disorder which is characterized by excessive production and accumulation of histiocytes in lymph nodes and extranodal sites.Extranodal involvement limited to the skin is known as cutaneous Rosai-Dorfman disease(CRDD).The clinical appearance of CRDD is non-specific.The pathologic features in cutaneous RDD include a dermal infiltrate of massive RDD cells,admixed with an infiltrate of lymphocytes and plasma cells.Emperipolesis is visible,which is the presence of intact infl ammatory cells like lymphocytes and neutrophils within the cytoplasm of histiocytes.CRDD is generally self-limited and usually does not require aggressive intervention.Surgery is considered to be the most effective treatment for small lesions.

关 键 词：ROSAI-DORFMAN病 皮肤 组织细胞增多症 

分 类 号：R751.02[医药卫生—皮肤病学与性病学] R751[医药卫生—临床医学]