T2WI门静脉周围信号强度与肝功能生化指标的相关性  

Correlation Between Periportal Hyperintensity of T2WI and Biochemical Indicators of Liver Function

作　　者：张烁 刘静静[1] 程敬亮[1] ZHANG Shuo;LIU Jingjing;CHENG Jingliang(Department of MRI,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院磁共振科,河南郑州450052

出　　处：《中国医学影像学杂志》2021年第4期367-371,共5页Chinese Journal of Medical Imaging

摘　　要：目的探讨肝功能损伤患者T2WI图像门静脉周围信号强度与肝功能生化指标的相关性。资料与方法回顾性分析65例肝功能损伤患者的MRI及实验室检查指标,其中,T2WI门静脉周围高信号(高信号组)42例,无高信号(非高信号组)23例。比较两组患者谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、总胆红素(TBil)、直接胆红素(DBil)、白蛋白及总蛋白的差异,分析门静脉周围高信号的出现与各项肝功能指标异常的相关性。绘制受试者工作特征(ROC)曲线,评估肝功能指标异常程度预测T2WI门静脉周围高信号出现的价值。结果高信号组ALT、AST、GGT、ALP、TBil、DBil水平显著高于非高信号组,白蛋白与总蛋白水平显著低于非高信号组,差异均有统计学意义(P<0.05)。AST、GGT、ALP、TBil、DBil、白蛋白及总蛋白预测T2WI门静脉周围高信号出现的ROC曲线下面积均>0.7。门静脉周围高信号的出现与GGT、ALP、TBil、DBil异常升高及白蛋白、总蛋白降低存在相关性(r=0.398、0.297、0.590、0.511、-0.320、-0.290,P<0.05)。结论肝功能损伤患者T2WI门静脉周围高信号的出现与GGT、ALP、TBil、DBil的异常升高及白蛋白、总蛋白降低存在相关性。T2WI门静脉周围高信号的出现预示肝功能损伤更严重。Purpose To investigate the correlation between periportal hyperintensity on T2WI and biochemical indicators of liver function in patients with liver function damage.Materials and Methods The clinical and MRI data of 65 patients with liver function damage were retrospectively analyzed,among which 42 patients with periportal hyperintensity(hyperintensity group)and 23 patients with no periportal hyperintensity(non-hyperintensity group)on T2WI.The differences of liver function biochemical indicators including alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyl transpeptidase(GGT),alkaline phosphatase(ALP),total bilirubin(TBil),direct bilirubin(DBil),albumin(Alb)and total protein(TP)were compared between the two groups,and correlations between the appearance of periportal hyperintensity and the abnormal liver function indicators were analyzed.Receiver operating characteristic(ROC)curve was drawn to evaluate the value of liver function indicators for the appearance of periportal hyperintensity on T2WI.Results The levels of ALT,AST,GGT,ALP,TBil and DBil in the hyperintensity group were significantly higher than those in non-hyperintensity group,while Alb and TP were significantly lower than those in non-hyperintensity group(P<0.05).The area under curve of ROC in AST,GGT,ALP,TBil,DBil,Alb and TP were all greater than 0.7.The appearances of periportal hyperintensity on T2WI were significantly associated with increased liver function indicators in GGT,ALP,TBil and DBil and decreased liver function indicators in Alb and TP(r=0.398,0.297,0.590,0.511,-0.320,-0.290,P<0.05).Conclusion The appearances of periportal hyperintensity are significantly associated with the abnormal increases of GGT,ALP,TBil,DBil and the decreases of Alb and TP in patients with liver function damage.The appearances of periportal hyperintensity on T2WI in patients with liver function damage predict more severe liver function damage.

关 键 词：肝功能不全 磁共振成像 门静脉 高信号 生物学标记 

分 类 号：R445.2[医药卫生—影像医学与核医学] R542.2[医药卫生—诊断学]