左西孟旦在老年重度心力衰竭治疗中的临床效果研究  

Study on clinical effect of levosimendan in the treatment of elderly severe heart failure

作　　者：王爱国[1] WANG Ai-guo(Chifeng Hospital,Chifeng 024000,China)

机构地区：[1]内蒙古赤峰市医院,024000

出　　处：《中国现代药物应用》2021年第9期12-14,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨左西孟旦在老年重度心力衰竭治疗中的临床效果。方法82例老年重度心力衰竭患者,按照随机数字表法分为对照组和左西孟旦组,每组41例。对照组采取多巴酚丁胺注射液治疗,左西孟旦组在对照组基础上加用左西孟旦注射液治疗。比较两组治疗效果、左心室射血分数达到50%的时间、住院时间及治疗前后左心室射血分数、6 min步行距离、脑钠肽水平。结果左西孟旦组患者治疗总有效率为95.12%,高于对照组的80.49%,差异具有统计学意义(P<0.05)。治疗后,左西孟旦组患者左心室射血分数(56.12±6.35)%高于对照组的(51.44±3.02)%,6 min步行距离(390.12±73.21)m长于对照组的(320.21±45.21)m,脑钠肽水平(104.12±12.24)pg/ml低于对照组的(246.15±24.05)pg/ml,差异具有统计学意义(P<0.05)。左西孟旦组患者左心室射血分数达到50%的时间、住院时间分别为(3.52±1.21)、(11.21±0.21)d,均短于对照组的(5.24±2.15)、(16.34±1.52)d,差异具有统计学意义(P<0.05)。结论左西孟旦注射液治疗重度心力衰竭的效果确切,可有效改善患者的心功能,提高患者运动耐力,纠正心力衰竭,加速症状改善,值得临床推广。Objective To discuss the clinical effect of levosimendan in the treatment of elderly severe heart failure.Methods A total of 82 elderly patients with severe heart failure were divided into control group and levosimendan group according to random numerical table,with 41 cases in each group.The control group was treated with dobutamine injection,and levosimendan group was treated with levosimendan injection on the basis of the control group.The therapeutic effect,time of left ventricular ejection fraction reached 50%,hospitalization time,left ventricular ejection fraction,6-min walking distance and brain natriuretic peptide before and after treatment were compared between the two groups.Results The total effective rate of levosimendan group was 95.12%,which was higher than 80.49%of the control group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular ejection fraction(56.12±6.35)%of levosimendan group was higher than(51.44±3.02)%of the control group,6-min walking distance(390.12±73.21)m was longer than(320.21±45.21)m of the control group,and brain natriuretic peptide(104.12±12.24)pg/ml was lower than(246.15±24.05)pg/ml of the control group.All the difference was statistically significant(P<0.05).The time of left ventricular ejection fraction reached 50%and hospitalization time of levosimendan group were(3.52±1.21)and(11.21±0.21)d,which were shorter than(5.24±2.15)and(16.34±1.52)d of the control group,and the difference was statistically significant(P<0.05).Conclusion Levosimendan injection provides affirmative effect in the treatment of patients with severe heart failure,which can effectively improve the cardiac function of patients,improve their exercise endurance,correct heart failure and accelerate the improvement of symptoms.It is worth clinical popularizing.

关 键 词：左西孟旦 老年重度心力衰竭 临床效果 

分 类 号：R541.6[医药卫生—心血管疾病]