无创通气治疗老年重症COPD急性加重期合并呼吸衰竭患者对其肺功能及预后的影响  

Effect of noninvasive ventilation on pulmonary function and prognosis of elderly patients with acute exacerbation of COPD and respiratory failure

作　　者：文昌宇 刘春漪 WEN Chang-yu;LIU Chun-yi(Chongqing Jiulongpo District People’s Hospital,Chongqing 400050,China)

机构地区：[1]重庆市九龙坡区人民医院呼吸与危重症学科,400050 [2]重庆医科大学附属第二医院呼吸与危重症学科,400010

出　　处：《中国现代药物应用》2021年第9期53-56,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究无创通气治疗老年重症慢性阻塞性肺疾病(COPD)急性加重期合并呼吸衰竭患者对其肺功能及预后的影响。方法62例老年重症COPD急性加重期合并呼吸衰竭患者,根据随机数字表法分为对照组和观察组,各31例。对照组采用常规基础性治疗,观察组在此基础上采用无创通气治疗。对比两组患者治疗前后肺功能指标、血气指标以及治疗有效率和成功率。结果治疗后,观察组用力肺活量占预计值的百分比(FVC%)、第1秒用力呼气容积(FEV1)、第1秒用力呼气容量积占用力肺活量的百分比(FEV1/FVC)分别为(60.52±8.75)%、(1.63±0.33)L、(62.74±10.36)%,均高于对照组的(54.62±9.41)%、(1.38±0.30)L、(57.21±10.65)%,差异具有统计学意义(P<0.05)。治疗后,观察组动脉血氧分压(PaO2)、pH高于对照组,动脉血二氧化碳分压(PaCO2)低于对照组,差异具有统计学意义(P<0.05)。观察组治疗有效率和成功率分别为90.32%、83.87%,均高于对照组的67.74%、61.29%,差异具有统计学意义(P<0.05)。结论无创通气治疗老年重症COPD急性加重期合并呼吸衰竭的效果良好,可改善患者的肺功能和血气指标,有利于患者病情恢复,缩短住院时间,值得临床应用。Objective To investigate the effect of noninvasive ventilation on pulmonary function and prognosis of elderly patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)and respiratory failure.Methods A total of 62 elderly patients with acute exacerbation of COPD and respiratory failure were divided into control group and observation group according to random numerical table,with 31 cases in each group.The control group received conventional basic treatment,and the observation group received noninvasive ventilation.The pulmonary function indicators and blood gas indicators before and after treatment,effective rate and success rate were compared between the two groups.Results After treatment,the forced vital capacity as a percentage of predicted value(FVC%),forced expiratory volume in the first second(FEV1)and FEV1/FVC of the observation group were(60.52±8.75)%,(1.63±0.33)L and(62.74±10.36)%,which were higher than(54.62±9.41)%,(1.38±0.30)L and(57.21±10.65)%of the control group,and the difference was statistically significant(P<0.05).After treatment,the arterial partial pressure of oxygen(PaO2)and pH of the observation group were higher than those of the control group,and arterial partial pressure of carbon dioxide(PaCO2)of the observation group were lower than that of the control group.All the difference was statistically significant(P<0.05).The effective rate and success rate of the observation group were 90.32%and 83.87%,which were all higher than 67.74%and 61.29%of the control group,and the difference was statistically significant(P<0.05).Conclusion Noninvasive ventilation shows good effect in the treatment of elderly patients with acute exacerbation of COPD,which can improve the pulmonary function and blood gas indicators,and shorten hospitalization time,and is beneficial to the recovery of the patient’s condition.It is worthy of clinical application.

关 键 词：重症慢性阻塞性肺疾病急性加重期 老年 无创通气 肺功能 预后 

分 类 号：R563.9[医药卫生—呼吸系统] R563.8[医药卫生—内科学]