绒促性素联合G-CSF宫内灌注对薄型子宫内膜不孕患者妊娠的影响  

Effect of intrauterine infusion of chorionic gonadotropin combined with G-CSF on pregnancy in patients with thin endometrial infertility

作　　者：贾姣姣[1] 陈辉莲[1] 唐慧珍[1] JIA Jiaojiao;CHEN Huilian;TANG Huizhen(Reproductive Medicine Center,Hunan Maternal and Child Health Hospital,Changsha 410008,Hunan,China)

机构地区：[1]湖南省妇幼保健院生殖医学中心,长沙410008

出　　处：《中国性科学》2021年第4期85-88,共4页Chinese Journal of Human Sexuality

摘　　要：目的探讨绒促性素联合粒细胞集落刺激因子(G-CSF)宫内灌注对薄型子宫内膜不孕患者妊娠的影响。方法选取2015年6月至2017年6月湖南省妇幼保健院收治的100例薄型子宫内膜不孕患者作为研究对象。按照随机数字表法分为灌注组(n=50)和联合组(n=50)。灌注组采用G-CSF宫内灌注治疗,联合组在灌注组基础上加用绒促性素进行治疗。对两组治疗前后临床指标、血管阻力指数(RI)、子宫动脉搏动指数(PI)、雌二醇(E_(2))、孕酮(P)、血管内皮生长因子(VEGF)、微血管密度(MVD)水平进行检测,统计妊娠率、治疗效果及不良反应发生情况。结果治疗后联合组子宫内膜厚度、卵泡直径,以及E_(2)、P、VEGF、MVD水平均高于灌注组,RI、PI低于灌注组,差异具有统计学意义(P<0.05);联合组治疗后妊娠率为94.00%(47例),显著高于灌注组80.00%(40例),差异具有统计学意义(χ^(2)=5.300,P=0.021)。联合组治疗总有效率为96.00%(48例),显著高于灌注组82.00%(41例),差异具有统计学意义(χ^(2)=5.986,P=0.014)。联合组治疗过程中不良反应发生率为14.00%(7例),高于灌注组8.00%(4例),但差异无统计学意义(χ^(2)=1.099,P=0.294)。结论绒促性素联合G-CSF宫内灌注可有效提高薄型子宫内膜不孕患者子宫内膜厚度及妊娠率,改善患者症状,效果显著。Objective To investigate the effect of intrauterine infusion of chorionic gonadotropin combined with granulocyte colony-stimulating factor(G-CSF)on pregnancy in patients with thin endometrial infertility.Methods A total of 100 patients with thin endometrial infertility treated in Hunan Maternal and Child Health Hospital from June 2015 to June 2017 were selected as the research subjects,and divided into perfusion group(n=50)and combined group(n=50)according to random number table method.Intrauterine perfusion therapy with G-CSF was used in the perfusion group,while the combined group was treated with chorionic gonadotropin on the basis of the perfusion group.Clinical indexes,vascular resistance index(RI),uterine arterial pulse index(PI),estradiol(E_(2)),progesterone(P),vascular endothelial growth factor(VEGF),microvascular density(MVD)levels were detected before and after treatment in the two groups,and pregnancy rate,treatment effect and the incidence of adverse reactions were counted.Results After treatment,endometrial thickness,follicle diameter,and levels of E_(2),P,VEGF and MVD in combined group were higher than those in perfusion group,while RI and PI were lower than those in perfusion group(P<0.05);the pregnancy rate in the combination group was 94.00%(47 cases),which was significantly higher than that in the perfusion group(80.00%,40 cases),and the difference was statistically significant(χ^(2)=5.300,P=0.021).The total effective rate(96.00%,48 cases)in the combined group was significantly higher than that in the perfusion group(82.00%,41 cases),and the difference was statistically significant(χ^(2)=5.986,P=0.014).The incidence of adverse reactions in the combination group was 14.00%(7 cases),which was higher than that in the perfusion group(8.00%),but the difference was not statistically significant(χ^(2)=1.099,P=0.294).Conclusions Intrauterine infusion of chorionic gonadotropin combined with G-CSF can effectively improve endometrial thickness and pregnancy rate in patients with thin endometrial inferti

关 键 词：绒促性素 粒细胞集落刺激因子 宫内灌注 薄型子宫内膜不孕 

分 类 号：R714[医药卫生—妇产科学]