卵母细胞人工激活的研究进展  

Progress of assisted oocyte activation

作　　者：赵昍朋 程东凯 于洪君 李宝山 ZHAO Xuanpeng;CHENG Dongkai;YU Hongjun;LI Baoshan(Fertility Center,Shenyang Jinghua Hospital,Shenyang 110005,Liaoning,China)

机构地区：[1]沈阳菁华医院生殖中心,沈阳110005

出　　处：《中国性科学》2021年第4期102-105,共4页Chinese Journal of Human Sexuality

摘　　要：受精时,精子诱导卵母细胞胞浆内Ca^(2+)发生一系列升高,成熟的卵母细胞激活进而继续发育,这个过程称为钙振荡。钙振荡在卵胞浆内单精子注射(ICSI)后也会出现,它主要由精子蛋白磷脂酶C-zeta(PLCζ)触发。目前,ICSI是使卵母细胞受精的有效方法,但一部分卵母细胞在ICSI后仍受精失败,这种情况似乎与PLCζ缺乏有关。在辅助生殖领域常通过卵母细胞人工激活(AOA)技术来改善受精失败患者的结局。本研究综述了卵母细胞激活的科学背景,并对AOA技术做了一些讨论。During fertilization,sperm induce a series of increases in the intracytoplasmic calcium ions concentration in the oocyte,the mature oocyte is activated and continues to develop,the process is known as calcium oscillations.Calcium oscillations also can appear after intracytoplasmic sperm injection(ICSI),it is mainly triggered by sperm protein phospholipase C-zeta(PLCζ).ICSI is an effective method of fertilization,but fertilization failure still exists in part of the oocytes,it seems to be related to PLCζdeficiency.In assisted reproduction,artificial oocyte activation is often used to improve the outcome of patients with fertilization failure.This article reviews the scientific background of oocyte activation and discussed artificial oocyte activation.

关 键 词：钙振荡 卵胞浆内单精子注射 磷脂酶C-zeta 卵母细胞人工激活 

分 类 号：R714[医药卫生—妇产科学]