中医治未病对不同体质高危型人乳头瘤病毒感染者的干预效果研究  

Intervention effect of traditional Chinese medicine on human papilloma virus infection with high risk type of different constitutions

作　　者：吕娜[1] 彭艳[1] 冯铁为[1] 王鸿波[2] LYU Na;PENG Yan;FENG Tiewei;WANG Hongbo(Center for Disease Prenention,the First Affiliated Hopital of Heilongiang Unioersity of Traditional Chinese Medicine,Ha'erbin 150040,Heilongiang,China;Department of Physical Diagnosis,the First Affiated Hospital of Heilongiang Unioersity of Traditional Chinese Medicine,Ha'erbin 150040,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学附属第一医院治未病中心,哈尔滨150040 [2]黑龙江中医药大学附属第一医院物理诊断科,哈尔滨150040

出　　处：《中国性科学》2021年第4期125-128,共4页Chinese Journal of Human Sexuality

基　　金：2017年度黑龙江中医药大学校科研基金项目(201721);中国博士后科学基金一等资助(2018M640315)。

摘　　要：目的观察并分析不同体质高危人乳头瘤病毒(HR-HPV)感染者经中医治未病干预的临床效果。方法选取2017年1月至2018年12月黑龙江中医药大学附属第一医院治未病中心招募的200例HR-HPV感染者作为研究对象。按照招募时间顺序分为实验组(n=100)和对照组(n=100)。实验组行中医治未病干预,对照组行常规药物干预,对比两组治疗效果。结果200名HR-HPV感染者中,中医体质类型主要为湿热质(22.50%)、气虚质(20.00%)和痰湿质(16.00%);干预前,两组临床症状积分、病毒载量、血清白介素-6(IL-6)水平比较,差异无统计学意义(P>0.05);干预后,实验组临床症状评分均低于对照组(P<0.05),病毒转阴率显著高于对照组(P<0.05),病毒载量和血清IL-6水平均低于对照组(P<0.05)。结论HR-HPV感染者经中医治未病干预后,患者临床症状改善,病毒转阴率提高,血清IL-6水平降低。治未病干预为HPV感染者癌变提供了有效的预防途径。Objective To observe and analyze the clinical effect of high-risk human papillom avirus(HR-HPV)infection with different risk factors of cervical cancer.Methods 200 patients with HR-HPV infection recruited from January 2017 to December 2018 in the Center for Disease Prevention of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine were selected as the research subjects.They were divided into experimental group(n=100)and control group(n=100)according to the chronological order of recruitment.The experimental group was treated without disease intervention,while the control group with conventional drug intervention.The treatment effect of the two groups was compared.Results Among the 200 patients with HR-HPV infection,the TCM constitution types were mainly damp and hot(22.50%),qi deficiency(20.00%)and phlegm and dampness(16.00%).Before intervention,there were no significant differences in clinical symptom score,viral load and serum interleukin-6(IL-6)levels between the two groups(P>0.05).After intervention,the clinical symptom score of the experimental group was lower than that of the control group(P<0.05),the virus conversion rate was significantly higher than that of the control group(P<0.05),the viral load and serum IL-6 level were lower than that of the control group(P<0.05).Conclusions After the intervention of TCM treatment,the clinical symptoms of the patients improved,the virus conversion rate increased,and the serum IL-6 value decreased.The intervention for treatment of the disease provides an effective way to prevent HPV infected persons from canceration.

关 键 词：中医 治未病 体质 宫颈癌 高危人乳头瘤病毒 感染 

分 类 号：R275[医药卫生—中医皮科]