基于DANTE预脉冲3D CUBE磁共振成像对动脉粥样硬化管壁重复性测量的实验研究  

Experimental Study on Repetitive Measurement of Atherosclerotic Vessel Wall based on DANTE Prepulse 3D CUBE Magnetic Resonance Imaging

作　　者：陈士跃 李帅 彭雯佳 陈录广 杨家诚 孙泽 陆建平 CHEN Shi-yue;LI Shuai;PENG Wen-jia;CHEN Lu-guang;YANG Jia-cheng;SUN Ze;LU jian-ping(Department of Imaging Medicine,The First Affiliated Hospital of PLA Naval Medical University,Shanghai 200433,China)

机构地区：[1]中国人民解放军海军军医大学第一附属医院影像医学科,上海200433

出　　处：《中国CT和MRI杂志》2021年第6期1-3,14,共4页Chinese Journal of CT and MRI

基　　金：国家自然科学基金(31600755,31470910)。

摘　　要：目的利用新西兰大白兔腹主动脉动脉粥样硬化模型探讨基于DANTE预脉冲CUBE序列对管壁成像定量测量的可重复性。方法采用高脂饲料喂养加腹主动脉内膜拉伤手术制作8只新西兰大白兔的动脉粥样硬化模型,同期普通饲料喂养2只作为对照组。运用3.0T MRI仪对兔的腹主动脉进行扫描,扫描序列包括常规2D横轴位FSE T2WI、FSE T1WI以定性观察管壁情况,3D冠状位黑血DANTE预备的CUBE T2WI和T1WI序列,以进行后续的定量评估。重复测量和计算腹主动脉的管腔面积(LA)、血管总面积(TA)及管壁面积(WA),统计变异系数(CV)和组内相关系数(ICC)以评估观察者间和观察者内的一致性。结果最终8只兔完成MRI检查,横轴位2D序列中以脂肪抑制T2WI显示管壁轮廓较佳,冠状位3D DANTE CUBE的T1WI和T2WI序列均可清晰显示实验组腹主动脉管壁不同程度增厚。病理检查示,3只实验组的管壁为AHAⅡ型斑块,另3只为AHAⅠ型斑块。DANTE CUBE成像的观察者内的一致性较高:T1WI和T2WI序列的LA、TA和WA的CV均小于15%;ICC均大于0.4。观察者间一致性也较高:除了DANTE CUBE T2WI序列的LA的CV稍大于15%(15.86%)以外,其余CV均小于15%;ICC均大于0.4。结论与2D磁共振管壁成像相比,DANTE黑血预备的3D CUBE序列扫描范围较大、时间效率较高,且空间分辨率可达到对动脉粥样硬化血管进行定量评估的要求。Objective To explore the repeatability of quantitative measurement of the vessel wall imaging based on DANTE prepulse CUBE sequence using the abdominal aortic atherosclerosis model of New Zealand white ra bbits.Methods Atherosclerosis model of eight New Zealand white ra bbits was esta blished by a high-fat diet and abdominal aortic intimal inju ry surgery.Two New Zealand white ra bbits were fed a normal diet during the same period as the control group.The ra bbit abdominal aorta was scanned by a 3.0 T MRI machine.The scanning sequence included conventional 2 D transverse FSE T_(2)WI and FSE T_(1)WI to observe the vessel wall qualitaticely,and 3 D coronal DANTE CUBE T_(2)WI and T_(1)WI sequences for quantitative evaluation.Lumen area(LA),total vascular area(TA),and wall area(WA)of the abdominal aorta were measured and calculated repeatedly.The variation coefficient(CV)and intragroup correlation coefficient(ICC)were counted to evaluate the consistency between and within observe rs.Results Finally,8 rabbits completed MRI examination.In the 2 D transverse position,fat suppression T2 WI was better to show the contour of the wall,and the T1 WI and T2 WI sequences of3 D DANTE CUBE in coronal position could clearly show the thickening of the abdominal aorta wall to different degrees in the experimental group.For Pathological exa mination,the wall of the AHAⅡtype plaque was found in three in the experimental group.Another 3 showed the AHA I plaque.DANTE CUBE imaging showed high consistency in the observers:the CV of LA,TA,and WA in T_(1) WI and T_(2) WI sequences were all less than 15%;ICC a re all greater than 0.4.There was also high consistency among the observers:except CV of the LA of DANTE CUBE T2 WI was slightly more than 15%(15.86%),CV of all the others was less than 15%;ICC a re all greater than 0.4.Condusion Compa red with 2 D magnetic resonance vessel wall imaging,the sca n ning ra nge of 3 D DANTE CUBE sequence is larger,with higher time efficiency,and the spatial resolution can meet the requirements for quan

关 键 词：磁共振 管壁 动脉粥样硬化 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743.1[医药卫生—诊断学]