氨基糖苷类抗菌药物的药学监护102例分析  

Pharmaceutical Care of 102 Cases of Aminoglycoside Antibiotics

作　　者：张晶磊 ZHANG Jinglei(Heze Traditional Chinese Medicine Hospital,Heze Shandong 274035,China)

机构地区：[1]菏泽市中医医院,山东菏泽274035

出　　处：《药品评价》2021年第6期356-358,共3页Drug Evaluation

摘　　要：目的:分析临床药师参与临床抗感染治疗中氨基糖苷类抗菌药物的药学监护实践与措施。方法:选取2018年6月至2020年11月菏泽市中医医院细菌感染患者102例,均使用氨基糖苷类抗菌药物治疗,进行药学监护,分析氨基糖苷类抗菌药物对肾功能[尿素氮(BUN)、血肌酐(SCr)]的影响。结果:治疗后患者血清BUN、SCr水平与治疗前相比,差异无统计学意义(P>0.05);不同年龄患者治疗前后组间血清BUN、SCr水平对比,差异无统计学意义(P>0.05);不同年龄患者治疗后血清BUN、SCr水平与同组治疗前对比,差异无统计学意义(P>0.05)。治疗过程中,均未见耳鸣、听力受损等耳毒性反应,未见神经肌肉阻滞不良反应。结论:在临床药师药学监护下,使用氨基糖苷类抗菌药物抗感染治疗,合理控制药物使用,可确保用药安全性,减轻肾毒性或其他不良反应。Objective:To analyze the pharmaceutical monitoring practices and measures of aminoglycosides in clinical antiinfective therapy by clinical pharmacists.Methods:102 cases of bacterial infection in Heze Traditional Chinese Medicine Hospital from June 2018 to November 2020,all were treated with aminoglycoside antibiotics,pharmaceutical supervision,the effects of aminoglycoside antibiotics on renal function[urea nitrogen(BUN),blood creatinine(SCr)]were analyzed.Results:There was no significant difference in serum BUN、SCr level after treatment compared with before treatment(P>0.05);there was no significant difference in serum BUN、SCr level between different age groups before and after treatment(P>0.05);there was no significant difference in serum BUN、SCr level between different ages and the same group before treatment(P>0.05).During the treatment,no ototoxic reactions such as tinnitus,hearing loss,there was no adverse reaction of neuromuscular block.Conclusion:Under the supervision of clinical pharmacists,anti-infective therapy with aminoglycoside antibiotics,rational control of drug use,to ensure safety,reduce nephrotoxicity or other adverse reactions.

关 键 词：药物监测 药学服务 抗感染治疗 氨基糖苷类抗菌药物 肾功能 不良反应 

分 类 号：R969[医药卫生—药理学]