辛伐他汀联合早期运动疗法对脑出血术后下肢深静脉血栓发生的预防效果及对血栓前标志物的影响  

Preventive Effect of Simvastatin Combined with Early Exercise Therapy on Lower Extremity Deep Venous Thrombosis after Cerebral Hemorrhage Surgery and Its Influence on Pre Thrombosis Markers

作　　者：冯景[1] FENG Jing(Dingzhou City People’s Hospital,Dingzhou 073000,China)

机构地区：[1]定州市人民医院,河北定州073000

出　　处：《中外医学研究》2021年第11期44-46,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析辛伐他汀联合早期运动疗法对脑出血术后下肢深静脉血栓发生的预防效果及对血栓前标志物的影响。方法:选取2019年7月-2020年3月本院收治的脑出血患者120例。根据随机数字表分组法将其分为观察组(n=60)和对照组(n=60)。对照组给予术后常规早期运动疗法,观察组在对照组基础上给予辛伐他汀治疗。比较两组术后不良事件发生率、血栓前标志物、凝血指标及术后股静脉血流速度指标。结果:观察组不良事件发生率8.33%,明显低于对照组的26.67%,其中观察组下肢深静脉血栓发生率明显低于对照组(P<0.05)。观察组术后2周PAI-1、GMP-140、vWF、FIB、PT、TT、APTT、D-D水平均明显优于对照组(P<0.05)。观察组术后2周血流峰速及平均速度均明显高于对照组(P<0.05)。结论:辛伐他汀联合早期运动疗法对预防脑出血术后下肢深静脉血栓发生的效果较好,可明显改善其术后凝血、血栓前标志物及股静脉血流速度指标,降低下肢血栓发生率,应用价值较高。Objective:To analyze the preventive effect of Simvastatin combined with early exercise therapy on lower extremity deep vein thrombosis after cerebral hemorrhage surgery and its influence on pre thrombus markers.Method:A total of 120 patients with intracerebral hemorrhage admitted to our hospital from July 2019 to March 2020 were selected.According to the random number table grouping method,they were divided into the observation group(n=60)and the control group(n=60).The control group was given routine early exercise therapy,and the observation group was given Simvastatin on the basis of the control group.The incidence of adverse events,prethrombotic markers,coagulation indexes and postoperative femoral vein blood flow velocity indexes were compared between the two groups.Result:The incidence of adverse events in the observation group(8.33%)was significantly lower than that in the control group(26.67%).The incidence of deep venous thrombosis in the observation group was significantly lower than that in the control group(P<0.05).The levels of PAI-1,GMP-140,vWF,FIB,PT,TT,APTT and D-D in the observation group were significantly better than those in the control group at 2 weeks after operation(P<0.05).The average velocity of blood flow and peak velocity in the observation group were significantly higher than those in the control group at 2 weeks after operation(P<0.05).Conclusion:Simvastatin combined with early exercise therapy has a good effect on preventing lower extremity deep vein thrombosis after cerebral hemorrhage surgery,which can significantly improve postoperative coagulation,pre thrombus markers and femoral vein blood flow velocity index,reduce the incidence of lower extremity thrombosis,and has high application value.

关 键 词：辛伐他汀 早期运动疗法 脑出血 下肢深静脉血栓 预防效果 血栓前标志物 

分 类 号：R651.12[医药卫生—外科学] R543.6[医药卫生—临床医学]