内镜下氩离子凝固术对胃息肉患者血清G-17、PGⅠ、PGR水平的影响  

Effect of Endoscopic Argon Plasma Coagulation on Serum Levels of G-17,PGⅠand PGR in Patients with Gastric Polyps

作　　者：钟名荣[1] 索标[1] 黄文忠[1] 张永红[1] 骆芸[1] 林淑芬 ZHONG Mingrong;SUO Biao;HUANG Wenzhong;ZHANG Yonghong;LUO Yun;LIN Shufen(Xiamen Hospital of Traditional Chinese Medicine,Xiamen 361009,China)

机构地区：[1]厦门市中医院,福建厦门361009

出　　处：《中外医学研究》2021年第11期53-56,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨内镜下氩离子凝固术(APC)对胃息肉患者血清胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原比值(PGR)水平的影响。方法:选择笔者所在医院2018年8月-2020年3月收治的89例胃息肉患者,采用掷硬币法将其分为对照组(n=45)和观察组(n=44)。对照组给予内镜下高频电切术治疗,观察组给予内镜下氩离子凝固术治疗。术后14 d,对比两组临床疗效、血清G-17、PGⅠ、PGR、炎症反应因子[C反应蛋白(CRP)]水平、应激指标水平[去甲肾上腺素(NE)、肾上腺素(E)、皮质醇(Cor)]及并发症发生情况。结果:观察组临床总有效率(95.45%)高于对照组(77.78%),差异有统计学意义(P<0.05)。术后两组血清G-17、PGⅠ、PGR水平均高于术前,且观察组各指标均高于对照组,差异均有统计学意义(P<0.05)。术后两组血清CRP、NE、E、Cor水平均低于术前,且观察组各指标均低于对照组,差异均有统计学意义(P<0.05)。两组并发症发生率比较差异无统计学意义(P>0.05)。结论:胃息肉患者经内镜下APC治疗,可提高血清G-17、PGⅠ、PGR水平,缓解炎症反应,减轻机体应激反应,疗效明显,且安全性高。Objective:To investigate the effect of endoscopic argon plasma coagulation(APC)on serum gastrin-17(G-17),pepsinogenⅠ(PGⅠ)and pepsinogen ratio(PGR)in patients with gastric polyps.Method:A total of 89 patients with gastric polyps in our hospital from August 2018 to March 2020 were selected and divided into the control group(n=45)and the observation group(n=44)by coin toss method.The control group was given endoscopic high-frequency electrotomy treatment,the observation group was given endoscopic argon plasma coagulation treatment,14 days after operation,the clinical efficacy,serum G-17,PGⅠ,PGR,inflammatory response factor[C-reactive protein(CRP)]levels,stress index levels[norepinephrine(NE),epinephrine(E),cortisol(COR)]and complications were compared between the two groups.Result:The total effective rate in the observation group(95.45%)was higher than that in the control group(77.78%),the difference was statistically significant(P<0.05).After surgery,the levels of serum G-17,PGⅠand PGR in the two groups were higher than those before surgery,and all indexes in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After surgery,the levels of serum CRP,NE,E and COR in the two groups were lower than those before surgery,and all indexes in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:Endoscopic APC treatment can improve the levels of serum G-17,PGⅠand PGR,relieve inflammatory reaction and stress response of the body,with obvious curative effect and high safety.

关 键 词：胃息肉 内镜下氩离子凝固术 胃泌素-17 胃蛋白酶原 

分 类 号：R656.61[医药卫生—外科学]