喉咽清口服液防治放射性口腔溃疡及咽炎的疗效研究  

Therapeutic Effect of Houyanqing Oral Liquid on Radiation Induced Oral Ulcer and Pharyngitis

作　　者：王贤文[1] 唐纯玉 朱镇华[1] 田道法[1] 鄢宁 佘文雅 WANG Xianwen;TANG Chunyu;ZHU Zhenhua;TIAN Daofa;YAN Ning;SHE Wenya(The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,Hunan 410007,China;Hunan Era Sunshine Pharmaceutical Co.,Ltd,Yongzhou,Hunan 425000,China;Hunan Engineering Technology Research Center for Anti-infection Traditional Chinese Medicine,Liuyang,Hunan 410300,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南时代阳光药业股份有限公司,湖南永州425000 [3]湖南省抗感染中药工程技术研究中心,湖南浏阳410300

出　　处：《湖南中医药大学学报》2021年第5期770-774,共5页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金项目(81973914)。

摘　　要：目的观察喉咽清口服液对放射性口腔溃疡及咽炎的防治效果。方法将60例头颈部肿瘤初次放射治疗的患者随机分为观察组及对照组,每组30例,观察组含漱并口服喉咽清口服液,对照组含漱并口服康复新液。观察两组从放疗前3天至放疗结束的放射性黏膜损伤发生时的累积辐射剂量、口腔及咽部黏膜损伤程度、黏膜损伤高峰出现与持续时间、黏膜损伤愈合时间、局部疼痛程度视觉模拟评分(visal analogue scale,VAS)评分。结果观察组患者开始出现放射性口腔溃疡及咽炎时的累积辐射剂量明显高于对照组,差异有统计学意义(P<0.05);观察组患者黏膜损伤程度、黏膜损伤高峰持续时间、黏膜损伤愈合时间、局部疼痛程度VAS评分均明显低于对照组,差异有统计学意义(P<0.05)。结论头颈肿瘤患者放疗期间配合喉咽清口服液含漱与口服能有效延缓放射性口腔溃疡及咽炎的发生,并缩短黏膜溃疡愈合时间,有效减轻临床不适症状,值得临床推广应用。Objective To investigate the therapeutic effect of a kind of herbal medicine preparation Houyanqing Oral Liquid(HYQOL)on radiation induced oral ulcer and pharyngitis.Methods 60 patients with head and neck tumor treated by radiotherapy were randomly divided into observation group and control group,with 30 patients in each group.The observation group was treated with gargle and oral HYQOL and the control group was treated with gargle and oral Kangfuxin Solution(KFXS).The cumulative radiation dose of radiation induced mucosal injury,the severe degree of oral and pharyngeal mucosa injury induced by radiation,the appearing and lasting time of radiation induced mucosal injury at its peak phase,the healing time for the surface of damaged mucosa,the visal analogue scale(VAS)scores for local pain were observed in the two groups from 3 days before radiotherapy to the end of radiotherapy.Results The cumulative radiation dose at the beginning of radiation induced oral ulcer and pharyngitis in the observation group was significantly higher than that in the control group,with statistical significance(P<0.05);the severe degree of radiation induced mucosal injury,the appearing and lasting time of radiation induced mucosal injury at its peak phase,the healing time for the surface of damaged mucosa,the VAS scores for local pain in the observation group were significantly lower than those in the control group,with statistical significance(P<0.05).Conclusions Combined with HYQOL gargle and oral administration during radiotherapy for patients with head and neck tumor can effectively delay the occurrence of radioactive oral ulcer and pharyngitis,shorten the healing time of mucosal ulcer,and effectively reduce clinical discomfort symptoms,which is worthy of clinical promotion and application.

关 键 词：放射性口腔溃疡 放射性咽炎 头颈肿瘤 喉咽清口服液 累积辐射剂量 黏膜损伤程度 黏膜损伤愈合时间 疼痛视觉模拟评分 

分 类 号：R28[医药卫生—中药学]