化浊祛痰法对冠心病患者临床疗效及免疫机制的影响  

Clinical Effects of Resolving Turbidity Eliminating Phlegm Method in Treating the Patients with CHD and Its Influence on Immune Mechanism

作　　者：朱红俊[1] 苏伟[1] 韩瑶瑶 周春刚[1] ZHU Hongjun;SU Wei;HAN Yaoyao;ZHOU Chungang(Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Wuxi 214001,China)

机构地区：[1]南京中医药大学无锡附属医院,江苏无锡214001

出　　处：《西部中医药》2021年第5期65-69,共5页Western Journal of Traditional Chinese Medicine

基　　金：江苏省第十三批“六大人才高峰”项目C类资助项目(WSN-244)。

摘　　要：目的:探讨化浊祛痰法对冠心病痰浊证患者临床疗效及淋巴细胞亚群分布的影响。方法:将冠心病痰浊证患者74例随机分为对照组和治疗组各37例,另设健康组39人。对照组采用标准化冠心病治疗方案,治疗组在对照组基础上加用化浊祛痰方治疗。观察两组临床疗效及淋巴细胞亚群等免疫学指标变化情况。结果:1)中医证候疗效方面,总有效率治疗组为94.6%(35/37),高于对照组的86.5%(32/37),差异有统计学意义(P<0.05);西雅图心绞痛量表积分方面,治疗组AS、AF积分高于对照组,差异具有统计学意义(P<0.05)。2)两组白细胞CD45,淋巴细胞CD3、CD4、CD19、CD192,单核细胞CD14均高于健康组;而淋巴细胞CD8,NK细胞CD16/CD56,单核细胞CD192低于健康组,差异具有统计学意义(P<0.05)。3)两组患者免疫功能均改善。其中治疗组在白细胞CD45,淋巴细胞CD3、CD8、CD192,单核细胞CD192的下降和淋巴细胞CD4、CD19、CD192,NK细胞CD16/CD56,单核细胞CD14的上升方面优于对照组,差异具有统计学意义(P<0.05)。结论:化浊祛痰法提高痰浊证冠心病患者临床疗效的机制可能与调节免疫功能有关。Objective:To explore clinical effects of resolving turbidity eliminating phlegm method in treating coronary heart disease(CHD)of phlegm turbidity pattern and its influence on the distribution of lymphocyte subsets.Methods:All 74 patients were randomized into the control group and the treatment group,37 cases in each group,and 39 persons of the healthy group was established.The control group adopted standardized treatment of CHD,and the treatment group took resolving turbidity eliminating phlegm prescription based on standardized treatment of CHD.To observe clinical efficacy,the changes of lymphocyte subsets and other immunological indexes between both groups.Results:1)Curative effects of TCM syndromes,total effective rate of the treatment group was 94.6%(35/37),higher than 86.5%(32/37)of the control group,and the difference had statistical meaning(P<0.05);on the scores of Seattle Angina pectoris scales,the treatment group was higher than the control group in AS and AF scores,and the difference was statistically significant(P<0.05).2)The control group and the treatment group were higher than the healthy group in the levels of leucocyte CD45,lymphocytes CD3,CD4,CD19,CD192 and monocyte CD14;while lower than the healthy group in lymphocyte CD8,NK cells CD16/CD56 and monocyte CD192,and the difference showed statistical meaning(P<0.05).3)The immune functions of the control group and the treatment group were improved,among them,the treatment group was superior to the control group in the decrease of leucocyte CD45,lymphocytes CD3,CD8,CD192 and monocyte CD192,the rise of lymphocytes CD4,CD19,CD192,NK cells CD16/CD56 and monocyte CD14,and the difference had statistical meaning(P<0.05).Conclusion:The mechanism of resolving turbidity eliminating phlegm method improving clinical effects of CHD patients might be related to regulating immune function.

关 键 词：冠心病 免疫功能 化浊祛痰法 临床疗效 

分 类 号：R541[医药卫生—心血管疾病]