极低体质量新生儿血清中KL-6、BNP水平与小儿支气管肺发育不全的相关分析  

Correlation analysis of KL-6,BNP in the serum and neonatal bronchopulmonary hypoplasia of very low birth weight newborns

作　　者：张秀亚[1] 夏明月[1] 刘彦岐 刘立宏 胡媛媛 韦春慧 黄伟[1] ZHANG Xiuya;XIA Mingyue;LIU Yanqi;LIU Lihong;HU Yuanyuan;WEI Chunhui;HUANG Wei(Department of Pediatrics,First Hospital of Qinhuangdao,Qinhuangdao,Hebei 066000,China)

机构地区：[1]河北省秦皇岛市第一医院儿科,河北秦皇岛066000

出　　处：《国际检验医学杂志》2021年第10期1242-1245,共4页International Journal of Laboratory Medicine

摘　　要：目的分析极低体质量新生儿血清中Ⅱ型肺泡细胞表面抗原(KL-6)、脑钠肽(BNP)水平及与小儿支气管肺发育不全的相关性。方法以该院2015年3月至2019年4月收治的200例极低体质量新生儿作为研究对象,其中合并小儿支气管肺发育不全新生儿67例纳入观察组,单纯性极低体质量新生儿133例纳入对照组。比较观察组与对照组,以及不同疾病严重程度新生儿的KL-6、BNP水平,分析小儿支气管肺发育不全严重程度与KL-6、BNP水平的相关性,以及小儿支气管肺发育不全的危险因素。结果观察组KL-6、BNP水平明显高于对照组,差异有统计学意义(P<0.05)。轻度组、中度组、重度组新生儿KL-6、BNP水平比较,差异有统计学意义(P<0.05)。通过两两比较发现,随着新生儿的疾病严重程度的升高,新生儿的KL-6、BNP水平呈现明显上升趋势。KL-6、BNP水平与新生儿的小儿支气管肺发育不全严重程度均呈正相关(r=0.336、0.441,P<0.001)。机械通气时间在7 d以上、给氧时间在25 d以上均为造成极低体质量新生儿合并支气管肺发育不全的独立危险因素。结论极低出生体质量新生儿生后血清中KL-6、BNP水平与小儿支气管肺发育不全关系密切。Objective To analyze the serum levels of typeⅡalveolar cell surface antigen(KL-6),brain natriuretic peptide(BNP)in newborns with very low birth weight and their correlations with neonatal bronchopulmonary hypoplasia in children.Methods From March 2015 to April 2019,200 newborns with very low body weight were selected into this study,among them,67 newborns with bronchopulmonary hypoplasia were included in observation group,and 133 newborns with simple very low body weight were included in control group.The levels of KL-6 and BNP in newborns of the two groups and the levels of KL-6 and BNP in newborns of different disease severity were compared,analyze the correlations between the severity of bronchopulmonary hypoplasia in newborns and the levels of KL-6 and BNP,as well as the risk factors of bronchopulmonary hypoplasia in newborns.Results The levels of KL-6 and BNP in observation group were significantly higher than those in control group,and the differences were statistically significant(P<0.05).There were significant differences on levels of KL-6 and BNP in mild group,moderate group and severe group(P<0.05).Through pair-to-pair comparison,it was found that the levels of KL-6 and BNP in newborns showed a significant upward trend with the increase of the severity of the disease.The levels of KL-6 and BNP positively correlated with the severity of neonatal bronchopulmonary hypoplasia(r=0.336,0.441,P<0.001).Mechanical ventilation for more than 7 d and oxygen for more than 25 d were independent risk factors for very low birth weight newborns complicated with bronchopulmonary hypoplasia.Conclusion There were significant correlations between the levels of KL-6,BNP and neonatal bronchopulmonary hypoplasia.

关 键 词：极低体质量新生儿 支气管肺发育不全 Ⅱ型肺泡细胞表面抗原 脑钠肽 

分 类 号：R446.1[医药卫生—诊断学]