丝氨酸蛋白酶抑制剂Serpins对昆虫免疫调控作用的研究进展  

Advances in research on serine protease inhibitors (Serpins) and their role in regulating insect immune systems

作　　者：周诗敏 谷启娟 黄健华 时敏[1] 陈学新[1] ZHOU Shi-Min;GU Qi-Juan;HUANG Jian-Hua;SHI Min;CHEN Xue-Xin(Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests,Institute of Insect Sciences,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江大学昆虫科学研究所,农业部作物病虫分子生物学重点实验室,杭州310058

出　　处：《应用昆虫学报》2021年第2期245-255,共11页Chinese Journal of Applied Entomology

基　　金：国家自然科学基金(31672079);浙江省自然科学基金(LZ18C140001,LR18C140001)。

摘　　要：丝氨酸蛋白酶抑制剂Serpins是一类参与调控多种生理过程的蛋白酶抑制剂,广泛存在于所有生命体中。本文以黑腹果蝇Drosophila melanogaster、黄粉虫Tenebrio molitor、烟草天蛾Manduca sexta为例,阐述Serpins在昆虫体内诱导抗菌肽产生的Toll信号通路和诱导黑化反应的酚氧化酶酶原(Prophenoloxidase,PPO)激活通路中的调控作用,并以病毒、线虫、细菌和真菌及寄生蜂为例,明确它们产生的Serpins对昆虫宿主免疫系统的调控作用,全面总结和综述了近年来具有Serpin domain结构域的典型Serpins对昆虫免疫的调控作用的研究进展。Serine protease inhibitors(Serpins) are involved in the regulation of various physiological processes common in all living organisms. In this review, we summarize recent published papers on insect serpins involved in the Toll signaling pathway, which produce antimicrobial peptides and regulate the prophenoloxidase(PPO) activation cascade which induces melanogenesis in model insects such as Drosophila melanoganster, Tenebrio molitor and Manduca sexta. In addition, we review research on serpins from entomopathogens, including viruses, nematodes, bacteria, fungi and parasitoids involved in the immuno-regulation of insect hosts.

关 键 词：昆虫免疫 丝氨酸蛋白酶抑制剂 Toll信号通路 PPO激活通路 昆虫病原生物 

分 类 号：Q965[生物学—昆虫学]