聚乙二醇干扰素α-2a联合RBV抗病毒治疗慢性丙型肝炎患者疗效及对血清HCV RNA水平和不良反应的影响  

Efficacy of Peginterferon α-2a Combined with RBV Antiviral Therapy in Patients with Chronic Hepatitis C and Its Effect on Serum HCV RNA Levels and Adverse Reactions

作　　者：张梅[1] 杨永生[1] 韩金鹏 周惠娟[2] 刘霞 ZHANG Mei;YANG Yongsheng;HAN Jinpeng;ZHOU Huijuan;LIU Xia(Cangzhou Infectious Disease Hospital,Cangzhou 061000,China;不详)

机构地区：[1]河北省沧州市传染病医院,河北沧州061000 [2]上海交通大学医学院附属瑞金医院

出　　处：《中国医学创新》2021年第12期127-130,共4页Medical Innovation of China

摘　　要：目的:探讨聚乙二醇干扰素α-2a联合利巴韦林抗病毒治疗慢性丙型肝炎患者的效果及对血清HCV RNA水平和不良反应的影响。方法:选取2018年1月-2019年1月本院收治的120例慢性丙型肝炎患者,采用随机数字表法分为研究组与对照组,每组60例。对照组予以聚乙二醇干扰素α-2a治疗,研究组予以聚乙二醇干扰素α-2a联合利巴韦林抗病毒治疗。比较两组病毒学应答效果、血清丙型肝炎病毒核糖核酸(HCV RNA)水平和不良反应。结果:研究组快速病毒学应答率(RVR)、完全早期病毒学应答率(EVR)、治疗结束应答率(ETVR)及持续应答率(SVR)均高于对照组,差异均有统计学意义(P<0.05)。两组治疗后血清HCV RNA均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:聚乙二醇干扰素α-2a联合RBV治疗慢性丙型肝炎患者的抗病毒疗效显著,RVR、EVR、ETVR、SVR率均高于单纯药物治疗,血清HCV RNA水平降低,且安全性较高。Objective:To explore the effect of Peginterferonα-2a combined with Ribavirin antiviral treatment in patients with chronic hepatitis C and its influence on serum HCV RNA levels and adverse reactions.Method:A total of 120 patients with chronic hepatitis C admitted to our hospital from January 2018 to January 2019 were selected,they were divided into the study group and the control group according to the random number table method,60 cases in each group.The control group was treated with Peginterferonα-2a,and the study group was treated with Peginterferonα-2a combined with Ribavirin antiviral therapy.The virological response effect,serum hepatitis C virus ribonucleic acid level(HCV RNA)and adverse reactions of two groups were compared.Result:The rapid virological response rate(RVR),complete early virological response rate(EVR),end treatment virological response rate(ETVR),and sustained response rate(SVR)of the study group were higher than those of the control group,and the differences were significant(P<0.05).The serum HCV RNA after treatment in two groups were lower than those of before treatment,and the study group was lower than that of the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was significantly lower than that in the control group,and the difference was significant(P<0.05).Conclusion:Peginterferonα-2a combined with RBV in the treatment of patients with chronic hepatitis C has a significant antiviral effect,the rates of RVR,EVR,ETVR,and SVR are higher than those of drug therapy alone,the serum HCV RNA level is reduced and the safety is high.

关 键 词：聚乙二醇干扰素Α-2A 利巴韦林 慢性丙型肝炎 抗病毒疗效 血清HCV RNA 不良反应 

分 类 号：R512.63[医药卫生—内科学]