乙肝肝硬化患者血清Lp-PLA2、Cys-C水平与病情程度相关性  

Correlation between serum Lp-PLA2,Cys-C levels and diseaseseverity in patients with hepatitis B cirrhosis

作　　者：何绍慧 段明玲 洪芹 陈皋[1] HE Shaohui;DUAN Mingling;HONG Qin;CHEN Gao(Department of Infection,Deyang People′s Hospital,Deyang,Sichuan 618000,China)

机构地区：[1]四川省德阳市人民医院感染科,四川德阳618000

出　　处：《公共卫生与预防医学》2021年第3期149-152,共4页Journal of Public Health and Preventive Medicine

基　　金：四川省卫生健康委员会科研课题(17PJ404)。

摘　　要：目的探讨乙肝肝硬化患者血清脂蛋白相关磷脂酶A2(Lp-PLA2)、胱抑素C(Cys-C)水平与病情程度相关性。方法回顾性分析德阳市人民医院2017年10月至2019年5月110例乙肝肝硬化患者临床资料,依照肝硬化Child-Pugh分级标准,分为A级(n=42)、B级(n=37)、C级(n=31),另选取同期健康体检者30例作为对照组,检测纳入对象血清Lp-PLA2、Cys-C水平,分析血清指标与疾病严重程度的相关性。结果乙肝肝硬化组血清Lp-PLA2、Cys-C含量高于对照组(P<0.05);A级患者血清Lp-PLA2、Cys-C含量低于B级,B级低于C级(P<0.05);血清Lp-PLA2、Cys-C联合检测评估A级与B级以及B级与C级肝硬化ROC曲线下面积分别为为0.875、0.837,高于单独Lp-PLA2判断曲线下面积0.772、0.750,高于单独Cys-C判断曲线下面积0.750、0.691(P<0.05);Spearmann等级相关性分析显示,血清Lp-PLA2、Cys-C水平与疾病严重程度呈现正相关(r=0.659、0.561,P<0.05)。结论乙肝肝硬化患者血清Lp-PLA2、Cys-C水平明显升高,且随着乙肝肝硬化病情加重有逐渐增高的趋势,与疾病严重程度呈现正相关,对肝硬化的分级具有诊断效能。Objective To explore the correlation between serum lipoprotein-related phospholipase A2(Lp-PLA2),cystatin C(Cys-C)levels and disease severity in patients with hepatitis B cirrhosis(HBC).Methods Clinical data of 110 HBC patients in the hospital from October 2017 to May 2019 were retrospectively analyzed.According to Child-Pugh classification criteria of liver cirrhosis,they were divided into grade A(n=42),grade B(n=37)and grade C groups(n=31).Another 30 healthy controls during the same period were enrolled as control group.The levels of serum Lp-PLA2 and Cys-C were detected.And their correlation with disease severity was analyzed.Results Levels of serum Lp-PLA2 and Cys-C in HBC group were higher than those in control group(P<0.05).The levels of serum Lp-PLA2 and Cys-C were the highest in grade C group,followed by grade B group and grade A group(P<0.05).The areas under the ROC curve(AUC)of serum Lp-PLA2 combined with Cys-C for evaluating grade A and B,grade B and C HBC were 0.875 and 0.837,which were higher than those of Lp-PLA2(0.772,0.750)and Cys-C(0.750,0.691)alone(P<0.05).Spearmann rank correlation analysis showed that levels of serum Lp-PLA2 and Cys-C were positively correlated with disease severity(r=0.659,0.561,P<0.05).Conclusion The levels of serum Lp-PLA2 and Cys-C are significantly increased in HBC patients,which are gradually increased with the aggravation of HBC.The two indexes are positively correlated with disease severity,which are of diagnostic efficiency for the classification of liver cirrhosis.

关 键 词：乙肝肝硬化 病情程度 脂蛋白相关磷脂酶A2 胱抑素 相关性 

分 类 号：R181[医药卫生—流行病学]