某地区HBV感染及肝硬化发病状况调查分析  

Investigation and analysis of HBV infection and relatedcirrhosis in a certain area

作　　者：谢艳[1] 罗凤莲[1] 寇艳[1] XIE Yan;LUO Fenglian;KOU Yan(Department of Infection,The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]成都医学院第一附属医院感染科,成都610500

出　　处：《公共卫生与预防医学》2021年第3期153-156,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的调查并分析某地区乙型肝炎病毒(HBV)感染及其肝硬化发病情况。方法对某地区2018年10月至2020年10月期间365例HBV感染患者相关资料予以回顾性分析,调查并分析患者各项资料以及HBV感染肝硬化发病情况。结果HBV感染患者年龄主要分布于31~50岁(61.92%),主要为男性(80.00%),症状表现为尿黄(66.30%)、食欲不振(57.53%)、乏力(46.85%),患者均存在谷草转氨酶、谷丙转氨酶异常上升以及高胆红素血症,35例患者出现肝功能衰竭,其中31例患者存活出院,3例患者行肝移植,1例患者出院后死亡;365例患者中HBV肝硬化患者82例,年龄主要分布于31~50岁(63.41%),主要为男性(80.00%),主要症状为腹胀(46.34%)、肝掌(39.02%)、黄疸(34.15%),均存在肝功能指标异常,35.37%并发原发性腹膜炎,25.61%并发电解质紊乱;87.80%患者好转出院,上消化道出血、肝性脑病、死亡发生率分别为7.32%、3.66%、1.22%;单因素与多因素分析结果显示,饮酒史、HBV-DNA水平、运动是HBV肝硬化影响因素(P<0.05)。结论HBV感染及相关肝硬化患者多以中年男性为主,而饮酒史、HBV-DNA水平以及运动是HBV感染患者病情进展为肝硬化重要影响因素。Objective To investigate and analyze the incidence of hepatitis B virus(HBV)infection and related cirrhosis in a certain area.Methods A retrospective investigation was performed on 365 patients with HBV infection in a certain area from October 2018 to October 2020.The relevant data of the patients and the incidence of HBV infection-related cirrhosis were analyzed to explore the influencing factors for liver cirrhosis caused by HBV infection.Results The age of patients with HBV infection was mainly 31-50 years old(61.92%),who were mainly males(80.00%).The symptoms included yellow urine(66.30%),loss of appetitte(57.53%)and fatigue(46.85%).There was abnormal increase of aspartate aminotransferase and alanine aminotransferase,and hyperbilirubinemia in patients.35 patients developed liver failure,of whcih 31 patients survived and were discharged,3 patients underwent liver transplantation and 1 patient died after discharge.Among the 365 patients,there were 82 cases with HBV-related cirrhosis,mainly aged between 31 and 50 years old(63.41%),who were mainly males(80.00%).The main symptoms included abdominal distension(46.34%),liver palm(39.02%)and jaundice(34.15%),and all were accompanied with abnormal liver function indexes.Of the 365 patients,35.37%of them were complicated with primary peritonitis,and 25.61%with electrolyte imbalance.In addition,87.80%of the patients improved and were discharged.The incidence rates of upper gastrointestinal bleeding,hepatic encephalopathy and death were 7.32%,3.66%and 1.22%,respectively.The results of univariate and multivariate analysis showed that drinking history,HBV-DNA level and exercise were the influencing factors of HBV-related cirrhosis(P<0.05).Conclusion Patients with HBV infection and related cirrhosis are mostly middle-aged men.Drinking history,HBV-DNA level and exercise are important influencing factors for HBV infection progression to cirrhosis.

关 键 词：HBV感染 肝硬化 发病状况 

分 类 号：R181[医药卫生—流行病学]