水通道蛋白1、5与肺水肿相关性研究进展  

Research Progress on the Correlation between Aquaporin 1,5 and Pulmonary Edema

作　　者：沈慧萍 麻海英 洒玉萍[1] 李永平[1] SHEN Huiping;MA Haiying;SA Yuping;LI Yongping(Qinghai University,Xining 810000,China;不详)

机构地区：[1]青海大学,青海西宁810000

出　　处：《中国医学创新》2021年第10期181-184,共4页Medical Innovation of China

基　　金：国家自然科学基金项目(81760890)。

摘　　要：肺水肿是临床常见的急危重症之一,是由于各种原因引起肺内液体平衡障碍,从而对机体气体交换产生影响的疾病。肺组织内正常的液体平衡对维持正常肺功能至关重要。水通道蛋白(aquapurin,AQP)是调节跨细胞水平衡的重要蛋白质,其中AQP1、AQP5是分布于下呼吸道的主要水通道蛋白,对维持肺组织中正常的液体转运与平衡起重要作用。本文就近年来有关AQP1、AQP5的分布、功能及其与肺水肿的相关性文章做一综述,以期为肺水肿的基础研究、临床诊治与预防提供新的思路与参考。Pulmonary Edema is one of the most common acute and severe diseases in clinic.It is caused by various reasons,which leads to the disorder of fluid balance in the lung and affects the gas exchange of the body.Normal fluid balance in lung tissue is essential to maintain normal lung function.Aquapurin(AQP)is an important protein regulating water balance across cells,among which AQP1 and AQP5 are the main aquaporins distributed in the lower respiratory tract and play an important role in maintaining normal fluid transport and balance in lung tissue.This article reviews the recent articles about the distribution and function of AQP1 and AQP5 and their correlation with pulmonary edema in order to provide new ideas and references for the basic research,clinical diagnosis,treatment and prevention of pulmonary edema.

关 键 词：AQP1 AQP5 肺水肿 

分 类 号：R563[医药卫生—呼吸系统]