新生儿缺氧缺血性脑病应用单唾液酸四己糖神经节苷脂钠注射液联合高压氧治疗的效果分析  

Effect Analysis of Monosialotetrahexosylganglioside Sodium Injection Combined with Hyperbaric Oxygen in the Treatment of Neonatal Hypoxic Ischemic Encephalopathy

作　　者：吴小玲[1] 黄翠兰[1] 王珍春 WU Xiaoling;HUANG Cuilan;WANG Zhenchun(The First Affiliated Hospital of Guangxi University of Science and Technology,Liuzhou 545000,China;不详)

机构地区：[1]广西科技大学第一附属医院,广西柳州545000

出　　处：《中国医学创新》2021年第11期12-15,共4页Medical Innovation of China

摘　　要：目的:探究新生儿缺氧缺血性脑病(HIE)应用单唾液酸四己糖神经节苷脂钠注射液联合高压氧治疗的效果。方法:选取2014年4月-2019年3月在本院接受治疗的78例HIE患儿。随机分为对照组和观察组,各39例。对照组予以高压氧治疗,观察组在此基础上联合单唾液酸四己糖神经节苷脂钠注射液治疗。比较两组症状改善时间、大脑中动脉血流动力学指标、血清学指标及预后情况。结果:观察组意识、肌张力、吸吮能力、原始反射恢复正常的时间均短于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组大脑中动脉的Vs、Vd、Vm均高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组的血清IGF-1、GH均高于对照组,sICAM-1低于对照组,差异均有统计学意义(P<0.05)。观察组治疗期间死亡率及随访1年的后遗症发生率均低于对照组,差异均有统计学意义(P<0.05)。结论:单唾液酸四己糖神经节苷脂钠注射液联合高压氧治疗HIE可缩短症状恢复时间,改善血流动力学,保护脑组织功能,降低死亡率及后遗症发生率。Objective:To explore the effect of Monosialotetrahexosylganglioside Sodium Injection combined with hyperbaric oxygen in the treatment of neonatal hypoxic ischemic encephalopathy(HIE).Method:A total of 78 children with HIE who received treatment in our hospital from April 2014 to March 2019 were selected.They were randomly divided into control group and observation group,39 cases in each group.The control group was treated with hyperbaric oxygen and the observation group was combined with Monosialotetrahexosylganglioside Sodium Injection on this basis.The time of symptom improvement,middle cerebral artery hemodynamics index,serological indexes and prognosis were compared between the two groups.Result:The consciousness,muscle tension,sucking ability and original reflex return to normal time of the observation group were all shorter than those of the control group,the differences were statistically significant(P<0.05).After treatment,the Vs,Vd and Vm of the middle cerebral artery in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,serum IGF-1 and GH in the observation group were higher than those in the control group,and sICAM-1 was lower than that in the control group,the differences were statistically significant(P<0.05).The mortality rate during treatment and the incidence of sequelae during 1 year follow-up in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Monosialotetrahexosylganglioside Sodium Injection combined with hyperbaric oxygen treatment of HIE can shorten symptom recovery time,improve hemodynamics,protect brain tissue function,and reduce mortality and sequelae.

关 键 词：新生儿缺氧缺血性脑病 单唾液酸四己糖神经节苷脂钠注射液 高压氧 

分 类 号：R722.1[医药卫生—儿科]