肥胖2型糖尿病患者BMI、WHR、BF%与胰岛素抵抗指数的相关性研究  

Correlation Study of BMI,WHR,BF%and Insulin Resistance Index in Obese Type 2 Diabetes Patients

作　　者：宁观华 赫玉峰 NING Guanhua;HE Yufeng(Zhongshan Tanzhou Hospital,Zhongshan 528467,China;不详)

机构地区：[1]广东省中山市坦洲医院,广东中山528467

出　　处：《中国医学创新》2021年第11期16-20,共5页Medical Innovation of China

基　　金：中山市医学科研项目(2020J397)。

摘　　要：目的:分析肥胖2型糖尿病(T2DM)患者体质量指数(BMI)、腰臀比(WHR)、体脂百分比(BF%)与胰岛素抵抗指数(HOMA-IR)的相关性。方法:选择2019年1-11月在本院住院的50例T2DM患者作为研究对象,按BMI不同分为肥胖组42例(BMI≥25 kg/m^(2))和非肥胖组8例(BMI<25 kg/m^(2)),肥胖组按WHR不同分为腹型肥胖组(n=23)和周围型肥胖组(n=19)。比较肥胖组和非肥胖组的临床资料、临床生化指标;比较三组胰岛素抵抗发生率;分析BMI、WHR、BF%与HOMA-IR的相关性以及BMI与WHR、BF%之间的相关性。结果:肥胖组与非肥胖组年龄、性别比较,差异均无统计学意义(P>0.05);肥胖组的BMI、WHR、BF%均高于非肥胖组,差异均有统计学意义(P<0.05)。肥胖组与非肥胖组的FPG比较,差异无统计学意义(P>0.05);肥胖组的FINS、HOMA-IR均高于非肥胖组,差异均有统计学意义(P<0.05)。所有T2DM患者整体胰岛素抵抗发生率为80.00%(40/50),其中腹型肥胖组的发生率为86.96%(20/23),周围型肥胖组为78.95%(15/19),非肥胖组为62.50%(5/8),三组比较差异有统计学意义(χ^(2)=0.23,P<0.05)。BMI、WHR、BF%与HOMA-IR均呈负相关(P<0.05),BMI与WHR、BF%均呈正相关(P<0.05)。结论:在肥胖T2DM患者中,通过TANITA法测得BF%,可更好地反映患者体脂含量,具有便捷、安全有效的优势,对于评估肥胖T2DM患者的胰岛素抵抗发生率精确度较高,对指导临床治疗具有一定的参考价值。Objective:To analyze the correlation between body mass index(BMI),waist-to-height ratio(WHR),body fat percentage(BF%)and insulin resistance index(HOMA-IR)in obese type 2 diabetes mellitus(T2DM)patients.Method:A total of 50 T2DM patients admitted to our hospital from January to November 2019 were selected as the study subjects.According to BMI,42 patients were in the obese group(BMI≥25 kg/m^(2))and 8 patients were in the non-obese group(BMI<25 kg/m^(2)).The obese group was divided into abdominal obesity group(n=23)and peripheral obesity group(n=19)according to different WHR.The clinical data and biochemical indexes of the obese group and the non-obese group were compared.The incidence of insulin resistance among the three groups was compared.The correlation between BMI,WHR,BF%and HOMA-IR as well as the correlation between BMI and WHR,BF%were analyzed.Result:There were no significant differences in age and sex between obese group and non-obese group(P>0.05),and the BMI,WHR,BF%of obese group were higher than those of non-obese group(P<0.05).There was no significant difference in FPG between the obese group and the non-obese group(P>0.05);the FINS and HOMA-IR of the obese group were higher than those of the non-obese group,with statistical significance(P<0.05).The overall incidence of insulin resistance in all T2DM patients was 80.00%(40/50),among which the incidence of abdominal obesity group was 86.96%(20/23),peripheral obesity group was 78.95%(15/19),and non-obesity group was 62.50%(5/8),the difference among the three groups was statistically significant(χ~2=0.23,P<0.05).BMI,WHR,BF%were negatively correlated with HOMA-IR(P<0.05),BMI was positively correlated with WHR and BF%(P<0.05).Conclusion:In obese T2DM patients,the measurement of BF%by TANITA method can better reflect the patient’s body fat content,which has the advantages of convenience,safety and effectiveness,it has a high accuracy in the assessment of the incidence of insulin resistance in obese T2DM patients,and has certain reference value for guidi

关 键 词：肥胖 T2DM BMI WHR BF% HOMA-IR 

分 类 号：R587.1[医药卫生—内分泌]