丹参注射液联合孟鲁司特钠对过敏性紫癜患儿炎症指标及SOCS-3、Gd-IgA1水平的影响  

Effects of Danshen Injection Combined with Montelukast Sodium on Inflammation Indexes and Levels of SOCS-3 and Gd-IgA1 in Children with Henoch-Schonlein Purpura

作　　者：李迎欣 LI Yingxin(Jiamusi Maternal and Child Health Hospital,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市妇幼保健院,黑龙江佳木斯154002

出　　处：《中国医学创新》2021年第11期76-79,共4页Medical Innovation of China

摘　　要：目的:探究丹参注射液联合孟鲁司特钠对过敏性紫癜(henoch-schonlein purpura,HSP)患儿炎症指标及半乳糖缺陷免疫球蛋白A1(Gd-IgA1)、细胞因子信号转导抑制因子-3(SOCS-3)mRNA表达水平的影响。方法:回顾性分析2017年7月-2018年12月本院收治的250例HSP患儿临床资料,将使用丹参注射液联合孟鲁司特钠治疗的127例患者纳入观察组,将使用孟鲁司特钠治疗的123例患者纳入对照组,两组均治疗14 d。比较两组治疗开始后症状消失时间;比较两组治疗前、治疗14 d后炎症因子[白介素(IL-6)、肿瘤坏死因子-α(TNF-α)]和Gd-IgA1、SOCS-3 mRNA的表达水平。结果:观察组皮肤紫癜消失时间短于对照组,差异有统计学意义(P<0.05)。治疗14 d后,两组IL-6、TNF-α及Gd-IgA1、SOCS-3 mRNA表达水平均较治疗前降低,且观察组比对照组更低,差异均有统计学意义(P<0.05)。结论:HSP患儿采用丹参注射液联合孟鲁司特钠治疗效果显著,可以加快症状消失,降低炎症反应,调节免疫功能,值得临床推广。Objective:To investigate the effects of Danshen Injection combined with Montelukast Sodium on inflammatory indexes and the expression levels of galactose deficiency immunoglobulin A1(Gd-IgA1)and cytokine signal transfection inhibitor-3(SOCS-3)mRNA in children with henoch-schonlein purpura(HSP).Method:The clinical data of 250 HSP children admitted to our hospital from July 2017 to December 2018 were retrospectively analyzed.127 patients treated with Danshen Injection combined with Montelukast Sodium were included in the observation group.123 patients treated with Montelukast Sodium were included in the control group,and both groups were treated for 14 d.The time of symptom disappearance between the two groups was compared;the expression levels of inflammatory factors[interleukin(IL-6),tumor necrosis factor-α(TNF-α)]and Gd-IgA1,SOCS-3 mRNA before and after 14 d of treatment were compared.Result:The disappearance time of skin purpura in the observation group was shorter than that in the control group,the difference was statistically significant(P<0.05).After 14 d of treatment,the expression levels of IL-6,TNF-αand Gd-IgA1,SOCS-3 mRNA in the two groups were lower than those before treatment,and the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:The treatment effect of Danshen Injection combined with Montelukast Sodium in children with HSP is significant,it can accelerate the disappearance of symptoms,reduce inflammatory response and regulate immune function,it is worthy of clinical promotion.

关 键 词：过敏性紫癜 丹参注射液 孟鲁司特钠 炎症指标 细胞因子信号转导抑制因子-3 半乳糖缺陷免疫球蛋白A1 

分 类 号：R725.5[医药卫生—儿科]