莫西沙星联合纤维支气管镜药物灌注对耐多药肺结核患者T细胞亚群、肺功能和肝功能的影响  

The Effect of Moxifloxacin Combined with Fiberbronchoscopy on T CellSubsets, Lung Function and Liver Function in Multidrug ResistantTuberculosis Patients

作　　者：郭武[1] 田霞 任伟 何文均[1] 刘泉[1] GUO Wu;TIAN Xia;REN Wei;HE Wen-jun;LIU Quan△(Department of Infectious Disease,Fuling Center Hospital of Chongqing City,Chongqing,408000,China)

机构地区：[1]重庆市涪陵中心医院感染科,重庆408000

出　　处：《现代生物医学进展》2021年第8期1541-1544,1506,共5页Progress in Modern Biomedicine

基　　金：重庆市涪陵区科技计划项目(FLKJ,2019ABB2032)。

摘　　要：目的:探讨莫西沙星联合纤维支气管镜药物灌注对耐多药肺结核患者T细胞亚群、肺功能和肝功能的影响。方法:选取2017年2月~2018年12月期间我院收治的90例耐多药肺结核患者,根据随机数字表法分为对照组(n=45,常规基础治疗)和研究组(n=45,莫西沙星联合纤维支气管镜药物灌注),比较两组患者痰菌转阴率、病灶吸收率、T细胞亚群、肺功能和肝功能。结果:研究组治疗6个月后的痰菌转阴率为88.89%(40/45),高于对照组的68.89%(31/45)(P<0.05)。研究组治疗6个月后的病灶吸收率为84.44%(38/45),高于对照组的64.44%(29/45)(P<0.05)。两组治疗6个月后第1 s用力呼气容积(FEV1)、用力肺活量(FVC)、每分钟最大通气量(MVV)占预计值百分比、总蛋白(TP)、CD4^(+)、CD4^(+)/CD8^(+)均升高,且研究组高于对照组(P<0.05);丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、CD8+均降低,且研究组低于对照组(P<0.05)。结论:莫西沙星联合纤维支气管镜药物灌注治疗耐多药肺结核,可有效阻止疾病进展,同时在改善患者T细胞亚群、肺功能和肝功能方面效果显著。Objective: To investigate the effect of moxifloxacin combined with bronchofiberscope on T cell subsets, lung function and liver function in Multidrug resistant tuberculosis patients. Methods: 90 Multidrug resistant tuberculosis patients in our hospital from February 2017 to December 2018 were selectd, they were divided into control group(n=45, routine basic treatment) and study group(n=45, moxifloxacin combined with bronchofiberscope drug perfusion) according to the random number table method. The sputum negative rate, focus absorption rate, T cell subsets, lung function and liver function were compared between the two groups. Results: The sputum negative rate of the study group was 88.89%(40/45), which was higher than 68.89%(31/45) of the control group(P<0.05). The absorption rate of focus in the study group was 84.44%(38/45), which was higher than 64.44%(29/45) in the control group(P<0.05). After 6 months of treatment, forced expiratory volume(FEV1), forced vital capacity(FVC), and maximum ventilation volume per minute(MVV) as a percentage of the predicted value, the total protein(TP), CD4+, CD4+/CD8+in the first second in the two groups were higher than those of the control group, and the study group were higher than the control group(P<0.05). Alanine aminotransferase(ALT), aspartate aminotransferase(AST) and CD8+decreased, and the study group was lower than that in the control group(P<0.05). Conclusion:Moxifloxacin combined with fiberbronchoscopic drug perfusion can effectively prevent the progress of the disease and improve the T cell subsets, lung function and liver function of the patients.

关 键 词：纤维支气管镜药物灌注 T细胞亚群 肺功能 莫西沙星 肝功能 耐多药肺结核 

分 类 号：R521[医药卫生—内科学]