恶性肿瘤细胞来源的外泌体调控自然杀伤细胞活性的相关机制  

Mechanisms related to regulation of natural killer cell activity by exosomes derived from malignant tumor cells

作　　者：鲁婷玮 张建军[1] 陈万涛[1] LU Ting-wei;ZHANG Jian-jun;CHEN Wan-tao(Department of Oral and Maxillofacial-Head&Neck Oncology,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海200011

出　　处：《上海交通大学学报（医学版）》2021年第5期659-664,共6页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81874126,81772933);上海市科学技术委员会科研计划项目(18JC1413700);上海交通大学医学院高水平地方高校创新团队(SSMU-ZLCX20180502)。

摘　　要：外泌体是一种细胞分泌的胞外小囊泡,在细胞之间发挥着传递信息的作用,通过物质的转运来调节各种细胞的生理和病理功能。有研究表明,外泌体直接或通过中间细胞作用于恶性肿瘤细胞,进而在恶性肿瘤的发生、发展中发挥着重要作用。近年来,自然杀伤(natural killer,NK)细胞与肿瘤细胞源性外泌体(tumor-derived exosomes,TDEXs)的相互作用和调控机制成为研究热点。在肿瘤微环境中,TDEXs可以作用于NK细胞,改变NK细胞与其他免疫细胞和免疫因子的相互作用,最终导致NK细胞对恶性肿瘤细胞的免疫防御减弱和免疫耐受产生。该文综述了不同恶性肿瘤组织中TDEXs对NK细胞活性的影响和可能的机制。Exosomes are a kind of extracellular vesicles that play the role of transmitting information among cells.Through transporting of substances to regulate the physiological and pathological functions of various cells,it can affect the progress of malignant tumors.Natural killer(NK)cell is an indispensable part of the human immune system,and is important in the development of cancers.In the tumor microenvironment,tumor-derived exosomes(TDEXs)can act on NK cells,adjusting their functions,and modifying the interaction between NK cells and other immune cells,resulting in the change of the immune response.In recent years,the research on the relationship between NK cells and tumor exosomes has become a hot topic.The effects of TDEXs from different cancers on the activities of NK cells are summarized in this paper.

关 键 词：恶性肿瘤 肿瘤细胞源性外泌体 自然杀伤细胞 活性 

分 类 号：R392.1[医药卫生—免疫学]