急性肺损伤动物模型建立的研究进展  

Research progress in animal model of acute lung injury

作　　者：付静怡 汪雷 杨异[1] FU Jing-yi;WANG Lei;YANG Yi(Department of Thoracic Surgery,Shanghai Sixth People's Hospital,Shanghai Jiao Tong University,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院胸外科,上海200233

出　　处：《上海交通大学学报（医学版）》2021年第5期690-694,共5页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：急性肺损伤(acute lung injury,ALI)是指由各种因素导致的低氧性呼吸衰竭,甚至急性呼吸窘迫综合征的发生。ALI的发病率和病死率均很高,但其发病机制研究和治疗手段的进展不大,因此,建立动物模型来模拟ALI十分必要。该文收集和整理近年来关于ALI动物模型的文献,对ALI模型动物的选用,以及肺损伤的评估方法进行综述,为ALI动物模型的建立提供参考。Acute lung injury(ALI)refers to the occurrence of hypoxic respiratory failure and even acute respiratory distress syndrome caused by various factors.The morbidity and fatality rate of ALI are very high,but the research on its pathogenesis and treatment methods has not made much progress.Therefore,it is very necessary to establish animal models to simulate acute lung injury.In this paper,the literature on animal models of ALI in recent years is collected and summarized,and the selection of animal models of acute lung injury and the evaluation methods of lung injury are reviewed,so as to provide reference for the establishment of animal models of ALI.

关 键 词：急性肺损伤 动物模型 动物实验 

分 类 号：R332[医药卫生—人体生理学]