达那唑联合曲普瑞林治疗女童特发性性早熟  

Efficacy of danazole combined with tripriline in the treatment of female idiopathic precocious puberty

作　　者：赵金玲 徐华 朱炜杰[1] 崔盈[1] 沈菡萏 ZHAO Jinling;XU Hua;ZHU Weijie;CUI Ying;SHEN Handan(Department of Pediatrics, The Affiliated Hospital of Jiangnan University, Wuxi 214000, Jiangsu, China)

机构地区：[1]江南大学附属医院儿科,江苏无锡214000

出　　处：《西部医学》2021年第5期697-700,共4页Medical Journal of West China

基　　金：江苏省自然科学基金(KB20094448)。

摘　　要：目的探讨达那唑联合曲普瑞林治疗女童特发性性早熟的临床疗效。方法选取2017年2月~2018年2月我院收治的50例门诊女性患儿作为研究对象。按照随机数表法分为观察组(n=27)和对照组(n=23)。观察组采用达那唑联合曲普瑞林治疗,对照组采用曲普瑞林治疗。比较两组身体发育指标(身高、体重、预测身高、骨龄)、血清激素指标[卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)]水平、子宫情况(子宫容积、卵巢容积、卵泡直径)、多囊卵巢综合征(PCOS)发生率、睾丸酮血症、胰岛素抵抗指数。结果治疗前,两组身体发育指标变化、血清激素指标水平、子宫情况比较差异均无统计学意义(P>0.05)。治疗后,两组身高、体重、预测身高、骨龄均显著高于治疗前,且观察组均高于对照组(P<0.05);两组血清FSH、LH、E2水平均显著低于治疗前,且观察组均低于对照组(P<0.05);两组子宫容积、卵巢容积、卵泡直径均显著低于治疗前,且观察组均低于对照组(P<0.05);两组POCS发生率、睾丸酮血症、胰岛素抵抗指数比较差异均无统计学意义(P>0.05)。结论达那唑联合曲普瑞林治疗女童特发性性早熟可延缓性腺成熟,改善血清激素水平,抑制患儿第二性征提前和生长发育,具有一定的安全性,取得较满意的治疗效果,可在临床推广应用。Objective To study the effect of danazol combined with tripriline in the treatment of female idiopathic precocious puberty.Methods 50 Female idiopathic precocious puberty received therapy from February 2017 to February 2018 in our hospital were selected as research objects.According to random number table,those patients were divided into the observation group(n=27)and the control group(n=23).The observation group treated with danazol combined with triptorelin,while the control group was treated with triptorelin.The changes of body development index,serum hormone level,uterine condition(uterine volume,ovarian volume,follicle diameter),POCS incidence,testosterone,insulin resistance index were compared between the two groups.Results The height,weight,predicted height and age in the observation group were significantly higher than those in the control group[(137.95±3.92)cm vs(135.07±3.81)cm,(26.43±3.91)kg vs(23.09±3.80)kg,(165.01±5.69)cm vs(159.01±5.60)cm,(9.85±0.65)years vs(8.97±0.65)years](P<0.05).FSH,LH and E2 were significantly lower than the control group[(1.61±0.52)IU/L vs(2.98±0.81)IU/L,(0.63±0.15)IU/L vs(0.97±0.18)IU/L,(9.85±2.51)ng/L vs(14.09±2.78)ng/L](P<0.05).Uterine volume,ovarian volume and follicle diameter were significantly lower than those in the control group[(3.05±0.39)mL vs(3.75±0.38)mL,(1.42±0.19)mL vs(1.75±0.21)mL,(4.17±0.96)mm vs(6.01±0.98)mm](P<0.05).There was no significant difference in the incidence of POCS,testosterone and insulin resistance index between the two groups(P>0.05).Conclusion Danazol combined with triptorelin in the treatment of female idiopathic precocious puberty can achieve satisfactory therapeutic effect,delay gonadal maturation,improve serum hormone and inhibit children's early secondary sexual characteristics and growth and development.

关 键 词：达那唑 曲普瑞林 女童特发性性早熟 血清激素 临床疗效 

分 类 号：R725.8[医药卫生—儿科]