儿茶酚胺抑素在缺血性心肌病伴心房纤颤患者中的检测意义  

Study of catestatin in ischemic cardiomyopathy patients with atrial fibrillation

作　　者：袁鹰 傅涛 荆忱 李洁 王曦[2] Yuan Ying;Fu Tao;Jing Chen;Li Jie;Wang Xi(Department of Cardiology,Air Force Army Medical Center,Beijing 100089,China)

机构地区：[1]解放军空军特色医学中心心内科,北京100089 [2]解放军总医院第二医学中心心内科

出　　处：《北京医学》2021年第2期110-113,共4页Beijing Medical Journal

摘　　要：目的探讨儿茶酚胺抑素(catestatin,CST)水平在缺血性心肌病(ischemic cardiomyopathy,ICM)伴心房纤颤患者中的作用。方法选取2014年10月至2017年10月于解放军空军特色医学中心及解放军总医院第二医学中心收治的ICM患者110例,同时选择46名健康人为对照组,ICM患者按是否存在心房纤颤分为ICM合并心房纤颤组(58例)和ICM未合并心房纤颤组(52例)。采用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)测定患者血浆CST水平。比较3组TG、LDL-C、血糖(blood glucose,Glu)、SCr、左房内径(left atrial diameter,LAD)、左室射血分数(left ventric-ular ejection fraction,LVEF)、左室舒张末期内径(left ventricular end-diastolic diameter,LVEDd)、N末端B型脑钠肽前体(N-terminal B-type natriuretic peptide,NT-proBNP)的变化,分析血浆CST水平与以上各项指标的相关性,评估CST在ICM合并心房纤颤诊治中的作用。结果ICM合并心房纤颤组的年龄、BMI、SBP、DBP、Glu、LDL-C、TG、SCr、LAD、LVEDd均显著高于对照组(P<0.05),LVEF则低于对照组(P<0.05)。ICM合并心房纤颤组血浆CST水平最低,Pearson相关分析显示,CST与SBP、DBP、Glu、LDL-C、LVEF呈正相关(P<0.05),与LAD、LVEDd、NT-proBNP呈负相关(P<0.05)。校正年龄、性别、血压、LAD、NT-proBNP等影响因素,CST仍是ICM合并心房纤颤的独立危险因素。结论CST水平在ICM伴心房纤颤患者中明显降低,其可能参与ICM患者心房纤颤的发生和发展。Objective To analyze plasma level of catestatin(CST)in ischemic cardiomyopathy patients with atrial fibrillation.Methods A total of 110 consecutive patients with ischemic cardiomyopathy were retrospectively studied,including 58 cases complicated with atrial fibrillation as observation group,and 52 cases without atrial fibrillation as control group.Forty-six health subjects with matched age and gender in medical examination were enrolled as blank control group.Plasma level of CST was measured by ELISA and intergroup difference was compared.Changes in TG,LDL-C,blood sugar,SCr,left atrial diameter(LAD),left ventricular ejection fraction(LVEF),left ventricular end-diastolic dimension(LVEDd)were compared among the three groups.Results Patients in ischemic cardiomyopathy with atrial fibrillation had significantly higher age,BMI,SBP,DBP,glucose,SCr,TG,LDL-C,LAD,LVEDd,and lower LVEF than those of blank control group(all P<0.05).Plasma CST level was lowest in ischemic cardiomyopathy with atrial fibrillation group in the three groups(P<0.05).Pearson correlation analysis showed that there were positive correlation between CST and SBP,DBP,glucose,LDL-C,LVEF(P<0.05).There were negative correlation between CST and LAD,LVEDd,NT-proBNP(P<0.05).The association remained after adjustment for age,gender,blood pressure,LAD and NT-proBNP by using multivariable logistic regression analysis.Conclusions Plasma CST level of patients in ischemic cardiomyopathy with atrial fibrillation is significantly decreased.The examination of plasma CST has significant clinical value in judgement of patient’s condition of atrial fibrillation.

关 键 词：儿茶酚胺抑素 缺血性心肌病 心房纤颤 

分 类 号：R541.75[医药卫生—心血管疾病] R542.2[医药卫生—内科学]