钯催化三卤化合物的合成研究  

The Study on the Synthesis of Trihalides Catalyzed by Palladium

作　　者：徐帆 李明洋 陈茜 徐平平 李敏 陈正旺[1] XU Fan;LI Mingyang;CHEN Xi;XU Pingping;LI Min;CHEN Zhengwang(School of Chemistry and Chemical Engineering,Gannan Normal University,Ganzhou 341000,China)

机构地区：[1]赣南师范大学化学化工学院,江西赣州341000

出　　处：《赣南师范大学学报》2021年第3期60-64,共5页Journal of Gannan Normal University

基　　金：江西省教育厅科技项目(GJJ201422);赣州市科技计划项目。

摘　　要：卤代烃是重要的合成中间体,在多个领域有广泛的应用.本论文报道以炔溴和拉电子烯烃为底物,PdCl_(2)为催化剂,CuCl_(2)提供氯源并作为氧化剂,乙腈为溶剂,通过烯炔偶联高效合成一系列三卤化合物的方法.值得注意的是,该类产物提供了不同类型的卤原子,在有机合成中有较好的潜在应用价值.Halogenated hydrocarbons are important synthetic intermediates and are widely used in many fields.This paper reports a method for efficiently synthesizing a series of trihalides by ene-yne coupling from bromoalkynes and electron-withdrawing olefins,PdCl_(2) as the catalyst,CuCl_(2) as the chloride source and oxidant in acetonitrile solvent.It is worth noting that this type of products provides different types of halogen atoms and has good potential application value in organic synthesis.

关 键 词：钯催化 三卤化合物 炔溴 偶联 

分 类 号：R91[医药卫生—药学]