康妇炎胶囊联合甲硝唑及头孢曲松钠治疗湿热瘀结型慢性盆腔炎临床研究  

Clinical Study on Kangfuyan Capsules Combined with Metronidazole and Ceftriaxone Sodium for Chronic Pelvic Inflammatory Disease with Dampness-Heat Accumulation Syndrome

作　　者：汤芝丽 TANG Zhili

机构地区：[1]长兴县人民医院妇产科,浙江长兴313100

出　　处：《新中医》2021年第7期64-68,共5页New Chinese Medicine

摘　　要：目的:观察应用康妇炎胶囊联合甲硝唑及头孢曲松钠治疗湿热瘀结型慢性盆腔炎的效果。方法:选取90例湿热瘀结型慢性盆腔炎患者作为研究对象,按随机数字表法分为研究组和对照组各45例。2组均予甲硝唑氯化钠注射液和注射用头孢曲松钠治疗,研究组加予康妇炎胶囊治疗。1周为1个疗程,2组均连续治疗2个疗程。统计2组治疗后的临床疗效及治疗期间不良反应的发生情况,观察治疗前后血清炎症因子[白细胞介素-1 (IL-1)、白细胞介素-2 (IL-2)、超敏C-反应蛋白(hs-CRP)]的变化,比较2组治疗前及治疗1、2个疗程后的疼痛视觉模拟评分法(VAS)评分。结果:治疗2个疗程后,研究组总有效率为97.78%,高于对照组的82.22%,差异有统计学意义(P<0.05)。2组IL-1、hs-CRP水平均较治疗前降低,IL-2水平均较治疗前升高,差异均有统计学意义(P<0.01);研究组IL-1、hs-CRP水平均低于对照组,IL-2水平高于对照组,差异均有统计学意义(P<0.01)。与同组治疗前比较,2组治疗1个疗程及2个疗程的疼痛VAS评分均降低(P<0.01)。与同组治疗1个疗程比较,2组治疗2个疗程的疼痛VAS评分均降低(P<0.01);研究组治疗1个疗程及2个疗程的疼痛VAS评分均低于对照组(P<0.01)。研究组不良反应发生率低于对照组,但差异无统计学意义(P>0.05)。结论:康妇炎胶囊联合甲硝唑及头孢曲松钠治疗湿热瘀结型慢性盆腔炎患者临床疗效较好,可有效减轻机体的炎症反应与疼痛程度,安全性较好。Objective:To observe the effect of Kangfuyan capsules combined with metronidazole and ceftriaxone sodium for chronic pelvic inflammatory disease with dampness-heat accumulation syndrome. Methods: A total of 90 cases of patients with chronic pelvic inflammatory disease with dampness-heat accumulation syndrome were selected, and were divided into the study group and the control group according to the random number table method,45 cases in each group.Both groups were given metronidazole and sodium chloride injection and injection of ceftriaxone sodium,and the study group was additionally given Kangfuyan capsules. Both groups were continuously treated for two courses, one week being a course. The clinical effect after treatment and the incidence of adverse reactions during treatment were statistically analyzed in the two groups. Changes in inflammatory factors in serum, namely interleukin-1(IL-1), interleukin-2(IL-2), and hypersensitivity C-reactive protein(hs-CRP) before and after treatment were observed. Scores of Visual Analogue Scale(VAS)of pain before treatment as well as after one course and two courses were compared between the two groups. Results:After two courses,the total effective rate was 97.78% in the study group,higher than that of 82.22% in the control group,the difference being significant(P<0.05). The levels of IL-1 and hs-CRP in the two groups were decreased when compared with those before treatment,and the levels of IL-2 were increased,differences being significant(P<0.01);the levels of IL-1 and hs-CRP in the study group were lower than those in the control group,and the level of IL-2 was higher than that in the control group,differences being significant(P<0.01). Compared with those in the same group before treatment,scores of VAS of pain in the two groups were decreased after one course and two courses(P<0.01). Compared with those in the same group after one course, scores of VAS of pain in the two groups were decreased after two courses(P<0.01). After one course and two courses,scores of VAS of

关 键 词：慢性盆腔炎 湿热瘀结证 康妇炎胶囊 炎症因子 

分 类 号：R711.33[医药卫生—妇产科学]