褪黑素在动物卵泡发育和闭锁中作用的研究进展  

Progress in the role of melatonin in animal follicular development and atresia

作　　者：张红春 李勇[1] 张岩[1] 孙玉姣 张震[2] 王永芬[2] ZHANG Hongchun;LI Yong;ZHANG Yan;SUN Yujiao;ZHANG Zhen;WANG Yongfen(College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China;College of Food and Bioengineering,Henan University of Animal Husbandry and Economy,Zhengzhou 450046,China)

机构地区：[1]河南农业大学动物医学院,郑州450046 [2]河南牧业经济学院食品与生物工程学院,郑州450046

出　　处：《黑龙江畜牧兽医》2021年第7期38-43,153,154,共8页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金青年基金项目(31802111);河南省科技攻关项目(192102110068;182102110302;20210211023)。

摘　　要：卵泡发育与闭锁是哺乳动物繁殖领域研究的热点。卵泡的发育和闭锁与生殖激素、氧化应激及凋亡蛋白等密切相关,而褪黑素在不同动物卵巢发育中的作用及机制已被大量研究,其不仅可以通过作用于下丘脑-垂体-性腺轴对促性腺激素进行调控,还能通过发挥抗氧化和抗凋亡能力调控动物的生殖机能。文章论述了褪黑素在促进动物卵泡发育、减少卵泡闭锁中作用的研究进展,旨在为利用褪黑素提高动物繁殖性能提供理论依据。Follicular development and atresia are the hot spots in the field of mammalian reproduction. Follicular development and atresia are closely related to reproductive hormones, oxidative stress and apoptotic proteins, etc. In different animals, the role and mechanism of melatonin in the ovarian development have been studied extensively. Melatonin can not only regulate gonadotropin by acting on the hypothalamus-pituitary-gonad axis, but also regulate reproductive function of animals by exerting antioxidant and anti-apoptotic abilities. In this paper, the progress of melatonin in promoting animal follicle development and reducing follicular atresia were reviewed, which was aim to provide a theoretical basis for improving animal reproductive performance by using melatonin.

关 键 词：褪黑素 卵泡发育 卵泡闭锁 活性氧(ROS) 抗氧化 抗凋亡 

分 类 号：S814.1[农业科学—畜牧学] Q576[农业科学—畜牧兽医]