新疆男男性行为人群队列失访率及其影响因素  

Lost to follow-up and its influencing factors among men who have sex with men in a cohort in Xinjiang Uygur Autonomous Region

作　　者：艾克丹·塔西 胡晓远[2] 倪祯 马媛媛[2] 倪明健[2] Aikedan·Taxi;HU Xiao-yuan;NI Zhen(Department of Epidemiology and Health Statistics,School of Public Health,Xinjiang Medical University,Urumqi,Xinjiang Uygur Autonomous Region 830011,China;不详)

机构地区：[1]新疆医科大学公共卫生学院流行病与卫生统计学教研室,新疆乌鲁木齐市830011 [2]新疆维吾尔自治区疾病预防控制中心性病与艾滋病科

出　　处：《中国公共卫生》2021年第4期651-654,共4页Chinese Journal of Public Health

基　　金：国家科技重大专项(2013ZX10004907,2011ZX10001–001,2009ZX10001–019)。

摘　　要：目的了解新疆男男性行为人群(MSM)队列失访率和随访保持率以及分析失访原因。方法于2010年6月—2015年3月在新疆乌鲁木齐市、伊宁市、阿克苏市3个地区招募HIV抗体阴性MSM,建立前瞻性队列研究。每3个月进行定位随访,每6个月进行行为学调查和HIV抗体检测。单因素分析采用多组比较的χ^(2)检验,多因素分析采用多元logistic回归。结果队列共纳入1041名调查对象,6个月随访人数900人(86.46%),12个月随访884人(84.92%);6个月失访141人(13.54%),12个月失访157人(15.08%).单因素分析结果显示,年龄、文化程度、户籍所在地、月收入、艾滋病相关知识、调查地区、参加队列原因、寻找性伴场所、安全套使用频次、近6个月性伴数量以及感染丙肝状况是MSM失访与随访之间的差异存在统计学意义的变量(P<0.05)。多因素分析结果显示,文化程度(OR=0.089,95%CI=0.060~0.133,P<0.001)、调查地区(OR=1.800,95%CI=1.231~2.632,P=0.002)、参加队列原因(OR=0.663,95%CI=0.465~0.946,P=0.023)、近6个月性伴数量(OR=4.070,95%CI=2.002~8.278,P<0.01)是队列失访的影响因素。结论新疆MSM队列失访率较高,文化程度、调查地区、参加队列研究的原因以及近6个月性伴数量均与队列失访有关。Objective To analyze the rate and associates of lost to follow-up in a cohort of men who have sex with men(MSM) initially negative for human immunodeficiency virus(HIV) in Xinjiang Uygur Autonomous Region(Xinjiang).Methods We sequentially recruited 1 041 MSM tested negative for HIV at the time of inclusion in 3 municipality regions of Xinjiang from June 2010 to March 2015 for a prospective cohort study. The participants of the study were followed-up every 3-month and were surveyed with a questionnaire interview on sex behavior and HIV antibody test every6-month. Results For all the participants, the number of being successfully interviewed was 900 and 884 at the time of 6 th month and 12 th month follow-up, with the ratios of 13.54% and 15.08% for being lost to follow-up, respectively. In univariate analysis, there were significant differences between the participants being followed-up and lost to followed-up in age, education, registered residence, monthly income, knowledge about HIV infection, current residential region, motivation for participating in the survey, setting of seeking sexual partners, frequency of condom use, number of sexual partners during previous 6 months, and hepatitis C virus infection(P < 0.05 for all). Multivariate logistic regression analysis revealed following significant impact factors for lost to followed-up: education(high vs. low: odds ratio [OR] = 0.089, 95%confidence interval [95% CI]: 0.060–0.133;P < 0.001), current residential region(metropolis vs. small and medium cities:OR = 1.800,95% CI: 1.231–2.632;P = 0.002), motivation for participating in the survey(to have HIV detection vs. others:OR = 0.663,95% CI: 0.465–0.946;P = 0.023), and the number of sexual partners during previous 6 months(high vs. low:OR = 4.070, 95% CI: 2.002–8.278;P < 0.001). Conclusion The rate of lost to followed-up is high among MSM involved in a prospective cohort in Xinjiang and the follow up among the MSM is mainly associated with education, current residential region, motivation for the particip

关 键 词：男男性行为 失访 前瞻性队列研究 

分 类 号：R181.2[医药卫生—流行病学]